Abstract
Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal-maternal interface.
Original language | English |
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Pages (from-to) | 135-150 |
Number of pages | 16 |
Journal | Seminars in Immunopathology |
Volume | 29 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jun 2007 |
Keywords
- Decidual macrophages
- Immunosuppression
- MIF
- Pregnancy
- Uterine NK cells
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy