The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface

Paola Viganò, Marcella Cintorino, Frederick Schatz, Charles J. Lockwood, Felice Arcuri

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal-maternal interface.

Original languageEnglish
Pages (from-to)135-150
Number of pages16
JournalSeminars in Immunopathology
Volume29
Issue number2
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Decidual macrophages
  • Immunosuppression
  • MIF
  • Pregnancy
  • Uterine NK cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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