The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface

Paola Viganò; Marcella Cintorino; Frederick Schatz; Charles J. Lockwood; Felice Arcuri

doi:10.1007/s00281-007-0074-3

The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface

Paola Viganò, Marcella Cintorino, Frederick Schatz, Charles J. Lockwood, Felice Arcuri

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal-maternal interface.

Original language	English
Pages (from-to)	135-150
Number of pages	16
Journal	Seminars in Immunopathology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1007/s00281-007-0074-3
Publication status	Published - Jun 2007

Keywords

Decidual macrophages
Immunosuppression
MIF
Pregnancy
Uterine NK cells

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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AU - Cintorino, Marcella

AU - Schatz, Frederick

AU - Lockwood, Charles J.

AU - Arcuri, Felice

PY - 2007/6

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AB - Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal-maternal interface.

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KW - Immunosuppression

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KW - Pregnancy

KW - Uterine NK cells

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The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface

Abstract

Keywords

ASJC Scopus subject areas

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