The role of magnetic resonance imaging in detecting intestinal fibrosis in Crohn's disease

Gionata Fiorino, Monica Cesarini, Alberto Malesci, Silvio Danese, Dario Sorrentino

Research output: Contribution to journalArticle

Abstract

One of the main challenges for clinicians dealing with Crohn's disease (CD) is to distinguish between inflammation and fibrosis, two sequential steps in the evolution of the intestinal disease. While inflammation is amenable to medical treatment, stricturing disease can only benefit from surgery. Magnetic resonance imaging (MRI) is a widely used tool in the diagnosis and assessment of CD. Recent data suggest that this technique might help in discriminating between fibrosis and inflammation and as such potentially guide medical decisions. In this review we will first highlight the main diagnostic techniques for CD. We will then briefly review the main mechanisms of fibrosis in this condition and the use of MRI in CD focusing on findings predictive of fibrosis and fibrotic evolution.

Original languageEnglish
Pages (from-to)1273-1279
Number of pages7
JournalCurrent Drug Targets
Volume13
Issue number10
DOIs
Publication statusPublished - 2012

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Keywords

  • Crohn's disease
  • Fibrosis
  • Inflammation
  • Inflammatory bowel disease
  • Intestinalstrictures
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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