The role of mass spectrometry in the "Omics" era

Francesco Di Girolamo, Isabella Lante, Maurizio Muraca, Lorenza Putignani

Research output: Contribution to journalArticle

Abstract

Mass spectrometry (MS) is one of the key analytical technology on which the emerging "-omics" approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a "global" or "targeted" manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies. In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.

Original languageEnglish
Pages (from-to)2891-2905
Number of pages15
JournalCurrent Organic Chemistry
Volume17
Issue number23
DOIs
Publication statusPublished - 2013

Keywords

  • Mass spectrometry
  • Meta-omics
  • MS
  • MS-based genomics
  • MS-based lipidomics
  • MS-based metabolomics
  • MS-based proteomics

ASJC Scopus subject areas

  • Organic Chemistry

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