The role of memory B cells in immunity after vaccination

Rita Carsetti; Alberto E. Tozzi

doi:10.1016/j.paed.2009.08.012

The role of memory B cells in immunity after vaccination

Rita Carsetti, Alberto E. Tozzi

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanism underlying the immunological memory induced by vaccines is not fully understood yet. Long lived plasma cells are generated in infants following an infection and are typically located in the bone marrow. Toll like receptors are essential for pathogen recognition, are expressed by T and B cells, and mediate the maturation of dendritic cells. Defects in expression of Toll Like Receptors are associated with susceptibility to infections. TLR9 is able to recognise the CpG motif in bacterial DNA and CpG oligodeoxynucleotides can be used to stimulate TLR9. TLR9 and CpG represent useful tools for exploring the size, specificity and function of the memory B cell pool induced by vaccination and antigen exposure. Through this mean we will be able to develop new sensitive methods to measure duration of protection against specific infections over time and consequently adjust immunisation schedules.

Original language	English
Journal	Paediatrics and Child Health
Volume	19
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/j.paed.2009.08.012
Publication status	Published - Dec 2009

Keywords

B-lymphocyte
immunological memory
toll like receptors
vaccines

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.paed.2009.08.012

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AB - The mechanism underlying the immunological memory induced by vaccines is not fully understood yet. Long lived plasma cells are generated in infants following an infection and are typically located in the bone marrow. Toll like receptors are essential for pathogen recognition, are expressed by T and B cells, and mediate the maturation of dendritic cells. Defects in expression of Toll Like Receptors are associated with susceptibility to infections. TLR9 is able to recognise the CpG motif in bacterial DNA and CpG oligodeoxynucleotides can be used to stimulate TLR9. TLR9 and CpG represent useful tools for exploring the size, specificity and function of the memory B cell pool induced by vaccination and antigen exposure. Through this mean we will be able to develop new sensitive methods to measure duration of protection against specific infections over time and consequently adjust immunisation schedules.

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The role of memory B cells in immunity after vaccination

Abstract

Keywords

ASJC Scopus subject areas

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