The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment

Marco D'Anzeo, Luca Faloppi, Mario Scartozzi, Riccardo Giampieri, Maristella Bianconi, Michela Del Prete, Nicola Silvestris, Stefano Cascinu

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.

Original languageEnglish
Pages (from-to)6393-6406
Number of pages14
JournalMolecules
Volume19
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • HCC
  • Hepatocellular carcinoma
  • MiRNAs

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

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