The role of microenvironment in tumor angiogenesis

Domenico Ribatti, Angelo Vacca

Research output: Contribution to journalArticle


Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in tumors and in multiple myeloma. The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalGenes and Nutrition
Issue number1
Publication statusPublished - 2008


  • Angiogenesis
  • Anti-angiogenesis
  • Metastasis
  • Microenvironment
  • Multiple myeloma
  • Tumor growth

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

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