The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases

G.P. Guerrini, F. Lo Faso, A. Vagliasindi, R. Lembo, L. Solaini, P. Soliani, M. Taviani, C. Porrello

Research output: Contribution to journalArticle

Abstract

Introduction: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. Methods: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed. Sixty-nine patients underwent major resection (68 thoracoscopic lobectomies and one pneumonectomy) and 155 patients underwent a wedge resection/segmentectomy. Complete curative pulmonary resections were performed in 219 (97%) cases. The Kaplan–Meier method was used to estimate survival curves. Univariate and subsequent multivariate Cox model regression were performed to identify independent factors of overall survival. Results: One hundred eighty-six patients developed lung metastases from epithelial tumors, 28 from sarcomas, seven from melanomas, and three from germ cell tumors. The final pathological examination revealed no cases of R1 disease. After a mean follow-up of 40 months, 118 patients (53%) had died. According to a multivariate analysis, a better prognosis was not observed for patients with a particular histological type; in addition, disease-free interval time, age, number of metastases, and type of surgery did not have any statistical influence on long-term survival. Conclusions: Thoracoscopic surgery is a safe and efficacious procedure, with a five-year overall survival that is equivalent to open surgery. Copyright © 2017 Taylor & Francis Group, LLC.
Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalJournal of Investigative Surgery
Volume30
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • CT scan technology
  • minimally invasive
  • morbidity
  • pulmonary metastasis
  • VATS surgery
  • adult
  • aged
  • Article
  • cancer patient
  • cancer prognosis
  • cancer surgery
  • cancer survival
  • disease free interval
  • epithelium tumor
  • female
  • germ cell tumor
  • human
  • long term survival
  • lung lobectomy
  • lung metastasis
  • lung resection
  • major clinical study
  • male
  • melanoma
  • metastasis resection
  • minimally invasive surgery
  • overall survival
  • priority journal
  • retrospective study
  • sarcoma
  • segmentectomy
  • survival rate
  • validity
  • video assisted thoracoscopic surgery
  • wedge resection
  • adverse effects
  • disease free survival
  • Kaplan Meier method
  • Lung Neoplasms
  • middle aged
  • mortality
  • neoplasm
  • pathology
  • perioperative period
  • procedures
  • prognosis
  • quality of life
  • secondary
  • treatment outcome
  • validation study
  • Aged
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Melanoma
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal
  • Neoplasms, Glandular and Epithelial
  • Perioperative Period
  • Pneumonectomy
  • Prognosis
  • Quality of Life
  • Retrospective Studies
  • Sarcoma
  • Thoracic Surgery, Video-Assisted
  • Treatment Outcome

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  • Cite this

    Guerrini, G. P., Lo Faso, F., Vagliasindi, A., Lembo, R., Solaini, L., Soliani, P., Taviani, M., & Porrello, C. (2017). The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases. Journal of Investigative Surgery, 30(2), 110-115. https://doi.org/10.1080/08941939.2016.1230246