The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases

G.P. Guerrini, F. Lo Faso, A. Vagliasindi, R. Lembo, L. Solaini, P. Soliani, M. Taviani, C. Porrello

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. Methods: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed. Sixty-nine patients underwent major resection (68 thoracoscopic lobectomies and one pneumonectomy) and 155 patients underwent a wedge resection/segmentectomy. Complete curative pulmonary resections were performed in 219 (97%) cases. The Kaplan–Meier method was used to estimate survival curves. Univariate and subsequent multivariate Cox model regression were performed to identify independent factors of overall survival. Results: One hundred eighty-six patients developed lung metastases from epithelial tumors, 28 from sarcomas, seven from melanomas, and three from germ cell tumors. The final pathological examination revealed no cases of R1 disease. After a mean follow-up of 40 months, 118 patients (53%) had died. According to a multivariate analysis, a better prognosis was not observed for patients with a particular histological type; in addition, disease-free interval time, age, number of metastases, and type of surgery did not have any statistical influence on long-term survival. Conclusions: Thoracoscopic surgery is a safe and efficacious procedure, with a five-year overall survival that is equivalent to open surgery. Copyright © 2017 Taylor & Francis Group, LLC.
Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalJournal of Investigative Surgery
Volume30
Issue number2
DOIs
Publication statusPublished - 2017

Fingerprint

Minimally Invasive Surgical Procedures
Neoplasm Metastasis
Lung
Metastasectomy
Video-Assisted Thoracic Surgery
Thoracoscopy
Survival
Therapeutics
Segmental Mastectomy
Pneumonectomy
Germ Cell and Embryonal Neoplasms
Proportional Hazards Models
Sarcoma
Melanoma
Multivariate Analysis
Quality of Life
Neoplasms

Keywords

  • CT scan technology
  • minimally invasive
  • morbidity
  • pulmonary metastasis
  • VATS surgery
  • adult
  • aged
  • Article
  • cancer patient
  • cancer prognosis
  • cancer surgery
  • cancer survival
  • disease free interval
  • epithelium tumor
  • female
  • germ cell tumor
  • human
  • long term survival
  • lung lobectomy
  • lung metastasis
  • lung resection
  • major clinical study
  • male
  • melanoma
  • metastasis resection
  • minimally invasive surgery
  • overall survival
  • priority journal
  • retrospective study
  • sarcoma
  • segmentectomy
  • survival rate
  • validity
  • video assisted thoracoscopic surgery
  • wedge resection
  • adverse effects
  • disease free survival
  • Kaplan Meier method
  • Lung Neoplasms
  • middle aged
  • mortality
  • neoplasm
  • pathology
  • perioperative period
  • procedures
  • prognosis
  • quality of life
  • secondary
  • treatment outcome
  • validation study
  • Aged
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Melanoma
  • Middle Aged
  • Neoplasms, Germ Cell and Embryonal
  • Neoplasms, Glandular and Epithelial
  • Perioperative Period
  • Pneumonectomy
  • Prognosis
  • Quality of Life
  • Retrospective Studies
  • Sarcoma
  • Thoracic Surgery, Video-Assisted
  • Treatment Outcome

Cite this

Guerrini, G. P., Lo Faso, F., Vagliasindi, A., Lembo, R., Solaini, L., Soliani, P., ... Porrello, C. (2017). The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases. Journal of Investigative Surgery, 30(2), 110-115. https://doi.org/10.1080/08941939.2016.1230246

The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases. / Guerrini, G.P.; Lo Faso, F.; Vagliasindi, A.; Lembo, R.; Solaini, L.; Soliani, P.; Taviani, M.; Porrello, C.

In: Journal of Investigative Surgery, Vol. 30, No. 2, 2017, p. 110-115.

Research output: Contribution to journalArticle

Guerrini, GP, Lo Faso, F, Vagliasindi, A, Lembo, R, Solaini, L, Soliani, P, Taviani, M & Porrello, C 2017, 'The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases', Journal of Investigative Surgery, vol. 30, no. 2, pp. 110-115. https://doi.org/10.1080/08941939.2016.1230246
Guerrini, G.P. ; Lo Faso, F. ; Vagliasindi, A. ; Lembo, R. ; Solaini, L. ; Soliani, P. ; Taviani, M. ; Porrello, C. / The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases. In: Journal of Investigative Surgery. 2017 ; Vol. 30, No. 2. pp. 110-115.
@article{36f88cac402a4a11a46a501e439745cd,
title = "The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases",
abstract = "Introduction: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. Methods: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed. Sixty-nine patients underwent major resection (68 thoracoscopic lobectomies and one pneumonectomy) and 155 patients underwent a wedge resection/segmentectomy. Complete curative pulmonary resections were performed in 219 (97{\%}) cases. The Kaplan–Meier method was used to estimate survival curves. Univariate and subsequent multivariate Cox model regression were performed to identify independent factors of overall survival. Results: One hundred eighty-six patients developed lung metastases from epithelial tumors, 28 from sarcomas, seven from melanomas, and three from germ cell tumors. The final pathological examination revealed no cases of R1 disease. After a mean follow-up of 40 months, 118 patients (53{\%}) had died. According to a multivariate analysis, a better prognosis was not observed for patients with a particular histological type; in addition, disease-free interval time, age, number of metastases, and type of surgery did not have any statistical influence on long-term survival. Conclusions: Thoracoscopic surgery is a safe and efficacious procedure, with a five-year overall survival that is equivalent to open surgery. Copyright {\circledC} 2017 Taylor & Francis Group, LLC.",
keywords = "CT scan technology, minimally invasive, morbidity, pulmonary metastasis, VATS surgery, adult, aged, Article, cancer patient, cancer prognosis, cancer surgery, cancer survival, disease free interval, epithelium tumor, female, germ cell tumor, human, long term survival, lung lobectomy, lung metastasis, lung resection, major clinical study, male, melanoma, metastasis resection, minimally invasive surgery, overall survival, priority journal, retrospective study, sarcoma, segmentectomy, survival rate, validity, video assisted thoracoscopic surgery, wedge resection, adverse effects, disease free survival, Kaplan Meier method, Lung Neoplasms, middle aged, mortality, neoplasm, pathology, perioperative period, procedures, prognosis, quality of life, secondary, treatment outcome, validation study, Aged, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Male, Melanoma, Middle Aged, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Perioperative Period, Pneumonectomy, Prognosis, Quality of Life, Retrospective Studies, Sarcoma, Thoracic Surgery, Video-Assisted, Treatment Outcome",
author = "G.P. Guerrini and {Lo Faso}, F. and A. Vagliasindi and R. Lembo and L. Solaini and P. Soliani and M. Taviani and C. Porrello",
note = "Cited By :1 Export Date: 20 February 2018 CODEN: JISUE Correspondence Address: Lo Faso, F.; Thoracic Surgery Unit, AUSL Romagna, S. Maria delle Croci HospitalItaly; email: feli_72@hotmail.com",
year = "2017",
doi = "10.1080/08941939.2016.1230246",
language = "English",
volume = "30",
pages = "110--115",
journal = "Journal of Investigative Surgery",
issn = "0894-1939",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - The Role of Minimally Invasive Surgery in the Treatment of Lung Metastases

AU - Guerrini, G.P.

AU - Lo Faso, F.

AU - Vagliasindi, A.

AU - Lembo, R.

AU - Solaini, L.

AU - Soliani, P.

AU - Taviani, M.

AU - Porrello, C.

N1 - Cited By :1 Export Date: 20 February 2018 CODEN: JISUE Correspondence Address: Lo Faso, F.; Thoracic Surgery Unit, AUSL Romagna, S. Maria delle Croci HospitalItaly; email: feli_72@hotmail.com

PY - 2017

Y1 - 2017

N2 - Introduction: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. Methods: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed. Sixty-nine patients underwent major resection (68 thoracoscopic lobectomies and one pneumonectomy) and 155 patients underwent a wedge resection/segmentectomy. Complete curative pulmonary resections were performed in 219 (97%) cases. The Kaplan–Meier method was used to estimate survival curves. Univariate and subsequent multivariate Cox model regression were performed to identify independent factors of overall survival. Results: One hundred eighty-six patients developed lung metastases from epithelial tumors, 28 from sarcomas, seven from melanomas, and three from germ cell tumors. The final pathological examination revealed no cases of R1 disease. After a mean follow-up of 40 months, 118 patients (53%) had died. According to a multivariate analysis, a better prognosis was not observed for patients with a particular histological type; in addition, disease-free interval time, age, number of metastases, and type of surgery did not have any statistical influence on long-term survival. Conclusions: Thoracoscopic surgery is a safe and efficacious procedure, with a five-year overall survival that is equivalent to open surgery. Copyright © 2017 Taylor & Francis Group, LLC.

AB - Introduction: The ideal surgical approach for pulmonary metastasectomy remains controversial. Thoracoscopic surgery may offer advantages in quality of life outcomes, with equivalent oncologic long-term results. This study aimed to demonstrate the validity of video-assisted thoracoscopic surgery (VATS) in the treatment of lung metastases. Methods: In all 224 patients who underwent 300 VATS metastasectomies from January 2000 to December 2013 were retrospectively reviewed. Sixty-nine patients underwent major resection (68 thoracoscopic lobectomies and one pneumonectomy) and 155 patients underwent a wedge resection/segmentectomy. Complete curative pulmonary resections were performed in 219 (97%) cases. The Kaplan–Meier method was used to estimate survival curves. Univariate and subsequent multivariate Cox model regression were performed to identify independent factors of overall survival. Results: One hundred eighty-six patients developed lung metastases from epithelial tumors, 28 from sarcomas, seven from melanomas, and three from germ cell tumors. The final pathological examination revealed no cases of R1 disease. After a mean follow-up of 40 months, 118 patients (53%) had died. According to a multivariate analysis, a better prognosis was not observed for patients with a particular histological type; in addition, disease-free interval time, age, number of metastases, and type of surgery did not have any statistical influence on long-term survival. Conclusions: Thoracoscopic surgery is a safe and efficacious procedure, with a five-year overall survival that is equivalent to open surgery. Copyright © 2017 Taylor & Francis Group, LLC.

KW - CT scan technology

KW - minimally invasive

KW - morbidity

KW - pulmonary metastasis

KW - VATS surgery

KW - adult

KW - aged

KW - Article

KW - cancer patient

KW - cancer prognosis

KW - cancer surgery

KW - cancer survival

KW - disease free interval

KW - epithelium tumor

KW - female

KW - germ cell tumor

KW - human

KW - long term survival

KW - lung lobectomy

KW - lung metastasis

KW - lung resection

KW - major clinical study

KW - male

KW - melanoma

KW - metastasis resection

KW - minimally invasive surgery

KW - overall survival

KW - priority journal

KW - retrospective study

KW - sarcoma

KW - segmentectomy

KW - survival rate

KW - validity

KW - video assisted thoracoscopic surgery

KW - wedge resection

KW - adverse effects

KW - disease free survival

KW - Kaplan Meier method

KW - Lung Neoplasms

KW - middle aged

KW - mortality

KW - neoplasm

KW - pathology

KW - perioperative period

KW - procedures

KW - prognosis

KW - quality of life

KW - secondary

KW - treatment outcome

KW - validation study

KW - Aged

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Neoplasms, Germ Cell and Embryonal

KW - Neoplasms, Glandular and Epithelial

KW - Perioperative Period

KW - Pneumonectomy

KW - Prognosis

KW - Quality of Life

KW - Retrospective Studies

KW - Sarcoma

KW - Thoracic Surgery, Video-Assisted

KW - Treatment Outcome

U2 - 10.1080/08941939.2016.1230246

DO - 10.1080/08941939.2016.1230246

M3 - Article

VL - 30

SP - 110

EP - 115

JO - Journal of Investigative Surgery

JF - Journal of Investigative Surgery

SN - 0894-1939

IS - 2

ER -