TY - JOUR
T1 - The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
AU - Bimonte, Sabrina
AU - Barbieri, Antonio
AU - Leongito, Maddalena
AU - Palma, Giuseppe
AU - Del Vecchio, Vitale
AU - Falco, Michela
AU - Palaia, Raffaele
AU - Albino, Vittorio
AU - Piccirillo, Mauro
AU - Amore, Alfonso
AU - Petrillo, Antonella
AU - Granata, Vincenza
AU - Izzo, Francesco
PY - 2016
Y1 - 2016
N2 - Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.
AB - Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.
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U2 - 10.1155/2016/8352684
DO - 10.1155/2016/8352684
M3 - Article
AN - SCOPUS:84960946148
VL - 2016
JO - Stem Cells International
JF - Stem Cells International
SN - 1687-966X
M1 - 8352684
ER -