The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Sabrina Bimonte; Antonio Barbieri; Maddalena Leongito; Giuseppe Palma; Vitale Del Vecchio; Michela Falco; Raffaele Palaia; Vittorio Albino; Mauro Piccirillo; Alfonso Amore; Antonella Petrillo; Vincenza Granata; Francesco Izzo

doi:10.1155/2016/8352684

The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Sabrina Bimonte, Antonio Barbieri, Maddalena Leongito, Giuseppe Palma, Vitale Del Vecchio, Michela Falco, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Antonella Petrillo, Vincenza Granata, Francesco Izzo

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

Original language	English
Article number	8352684
Journal	Stem Cells International
Volume	2016
DOIs	https://doi.org/10.1155/2016/8352684
Publication status	Published - 2016

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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title = "The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells",

abstract = "Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.",

author = "Sabrina Bimonte and Antonio Barbieri and Maddalena Leongito and Giuseppe Palma and {Del Vecchio}, Vitale and Michela Falco and Raffaele Palaia and Vittorio Albino and Mauro Piccirillo and Alfonso Amore and Antonella Petrillo and Vincenza Granata and Francesco Izzo",

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AU - Bimonte, Sabrina

AU - Barbieri, Antonio

AU - Leongito, Maddalena

AU - Palma, Giuseppe

AU - Del Vecchio, Vitale

AU - Falco, Michela

AU - Palaia, Raffaele

AU - Albino, Vittorio

AU - Piccirillo, Mauro

AU - Amore, Alfonso

AU - Petrillo, Antonella

AU - Granata, Vincenza

AU - Izzo, Francesco

PY - 2016

Y1 - 2016

N2 - Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

AB - Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

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The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Abstract

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