Il ruolo dei mitocondri sul danno da riperfusione coronarica come potenziale target farmacologico: Luci ed ombre

Translated title of the contribution: The role of mitochondria in the coronary reperfusion injury as a potential drug target: Bright and dark sides

Roberto Latini, Lidia Staszewsky, Filippo Ottani

Research output: Contribution to journalArticle

Abstract

Reperfusion of an occluded coronary artery is the most effective intervention in reducing cardiac injury which occurs as a consequence of an acute myocardial infarction. However, reperfusion per se may exacerbate the extent of myocardial injury which started at the onset of ischemia, thus leading to the so-called "reperfusion injury". The published studies in the last few years provide new hopes on the mitochondrion and its role in ischemia/reperfusion injury, through the modulation of the mitochondrial permeability pore. After very encouraging experimental data, two clinical trials are presented, CIRCUS and CYCLE, which should help addressing the still outstanding question: may an intervention targeted to decrease the permeability of the mitochondrial pore during reperfusion reduce infarct size and improve clinical outcomes of patients with myocardial infarction undergoing primary percutaneous coronary intervention?.

Original languageItalian
Pages (from-to)544-548
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Myocardial Reperfusion
Reperfusion Injury
Reperfusion
Mitochondria
Permeability
Myocardial Infarction
Pharmaceutical Preparations
Wounds and Injuries
Percutaneous Coronary Intervention
Coronary Vessels
Ischemia
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Il ruolo dei mitocondri sul danno da riperfusione coronarica come potenziale target farmacologico : Luci ed ombre. / Latini, Roberto; Staszewsky, Lidia; Ottani, Filippo.

In: Giornale Italiano di Cardiologia, Vol. 16, No. 10, 01.10.2015, p. 544-548.

Research output: Contribution to journalArticle

@article{2bf440340e114554981b0edf00eb462e,
title = "Il ruolo dei mitocondri sul danno da riperfusione coronarica come potenziale target farmacologico: Luci ed ombre",
abstract = "Reperfusion of an occluded coronary artery is the most effective intervention in reducing cardiac injury which occurs as a consequence of an acute myocardial infarction. However, reperfusion per se may exacerbate the extent of myocardial injury which started at the onset of ischemia, thus leading to the so-called {"}reperfusion injury{"}. The published studies in the last few years provide new hopes on the mitochondrion and its role in ischemia/reperfusion injury, through the modulation of the mitochondrial permeability pore. After very encouraging experimental data, two clinical trials are presented, CIRCUS and CYCLE, which should help addressing the still outstanding question: may an intervention targeted to decrease the permeability of the mitochondrial pore during reperfusion reduce infarct size and improve clinical outcomes of patients with myocardial infarction undergoing primary percutaneous coronary intervention?.",
author = "Roberto Latini and Lidia Staszewsky and Filippo Ottani",
year = "2015",
month = "10",
day = "1",
doi = "10.1714/2028.22036",
language = "Italian",
volume = "16",
pages = "544--548",
journal = "Giornale Italiano di Cardiologia",
issn = "1827-6806",
publisher = "CEPI s.r.l.",
number = "10",

}

TY - JOUR

T1 - Il ruolo dei mitocondri sul danno da riperfusione coronarica come potenziale target farmacologico

T2 - Luci ed ombre

AU - Latini, Roberto

AU - Staszewsky, Lidia

AU - Ottani, Filippo

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Reperfusion of an occluded coronary artery is the most effective intervention in reducing cardiac injury which occurs as a consequence of an acute myocardial infarction. However, reperfusion per se may exacerbate the extent of myocardial injury which started at the onset of ischemia, thus leading to the so-called "reperfusion injury". The published studies in the last few years provide new hopes on the mitochondrion and its role in ischemia/reperfusion injury, through the modulation of the mitochondrial permeability pore. After very encouraging experimental data, two clinical trials are presented, CIRCUS and CYCLE, which should help addressing the still outstanding question: may an intervention targeted to decrease the permeability of the mitochondrial pore during reperfusion reduce infarct size and improve clinical outcomes of patients with myocardial infarction undergoing primary percutaneous coronary intervention?.

AB - Reperfusion of an occluded coronary artery is the most effective intervention in reducing cardiac injury which occurs as a consequence of an acute myocardial infarction. However, reperfusion per se may exacerbate the extent of myocardial injury which started at the onset of ischemia, thus leading to the so-called "reperfusion injury". The published studies in the last few years provide new hopes on the mitochondrion and its role in ischemia/reperfusion injury, through the modulation of the mitochondrial permeability pore. After very encouraging experimental data, two clinical trials are presented, CIRCUS and CYCLE, which should help addressing the still outstanding question: may an intervention targeted to decrease the permeability of the mitochondrial pore during reperfusion reduce infarct size and improve clinical outcomes of patients with myocardial infarction undergoing primary percutaneous coronary intervention?.

UR - http://www.scopus.com/inward/record.url?scp=84948158328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948158328&partnerID=8YFLogxK

U2 - 10.1714/2028.22036

DO - 10.1714/2028.22036

M3 - Articolo

C2 - 26444212

AN - SCOPUS:84948158328

VL - 16

SP - 544

EP - 548

JO - Giornale Italiano di Cardiologia

JF - Giornale Italiano di Cardiologia

SN - 1827-6806

IS - 10

ER -