The role of morpho-volumetric and memory correlations in the diagnosis of early Alzheimer dementia

Marco Mauri, Luisella Sibilla, Giorgio Bono, Giovanni Augusto Carlesimo, Elena Sinforiani, Adelaide Martelli

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to assess selective atrophy of the temporal lobe and amygdala in the early stages of Alzheimer dementia (AD). Magnetic resonance imaging (MRI) measurements and the presence of highsignal lesions (HSL) were analysed in 31 patients with mild to moderate probable AD and 22 controls. In the AD group, MRI findings were compared with cognitive variables and specific features of memory functions. Alzheimer patients showed a significant reduction in volumetric measurement compared with controls in the total volume (P <0.01), temporal lobe (P <0.01) and amygdala (P <0.05). The temporal lobe/brain volume ratio was also significantly reduced in AD subjects (P <0.05). Atrophy of temporal structures was significantly related to the degree of episodic and semantic memory impairment according to a material-specific effect. No significant correlations between amygdala and cognitive variables were found. The results of our study confirm the usefulness of measures of temporal lobe atrophy assessed with MRI in the diagnosis of AD. In contrast, HSL are relatively common in AD patients (12/31 cases) and were not related to volumetric findings, severity of dementia or functional disability.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalJournal of Neurology
Volume245
Issue number8
DOIs
Publication statusPublished - 1998

Fingerprint

Alzheimer Disease
Temporal Lobe
Amygdala
Atrophy
Magnetic Resonance Imaging
Episodic Memory
Semantics
Dementia
Brain

Keywords

  • Alzheimer dementia
  • Amygdala
  • High signal lesions
  • Magnetic resonance imaging
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

The role of morpho-volumetric and memory correlations in the diagnosis of early Alzheimer dementia. / Mauri, Marco; Sibilla, Luisella; Bono, Giorgio; Carlesimo, Giovanni Augusto; Sinforiani, Elena; Martelli, Adelaide.

In: Journal of Neurology, Vol. 245, No. 8, 1998, p. 525-530.

Research output: Contribution to journalArticle

Mauri, Marco ; Sibilla, Luisella ; Bono, Giorgio ; Carlesimo, Giovanni Augusto ; Sinforiani, Elena ; Martelli, Adelaide. / The role of morpho-volumetric and memory correlations in the diagnosis of early Alzheimer dementia. In: Journal of Neurology. 1998 ; Vol. 245, No. 8. pp. 525-530.
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