The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.

M. Sbacchi, A. La Regina, P. Petrillo, A. Tavani

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Abstract

The agonist effects on intestinal transit of relatively selective mu- and delta- ligands, administered intraperitoneally, and their antagonism by the preferentially mu- and delta- antagonists naloxone and ICI 174,864 were studied in rats 5 min after a charcoal meal. The dose-response curves of the preferential mu- ligands morphine and [D-Ala2, MePhe4, Gly-ol5] enkephalin (DAGO) were shifted by naloxone at low doses but not by ICI 174,864. The preferential delta-peptide [D-Pen2, D-Pen5] enkephalin (DPDPE) had no significant agonist activity. [D-Ala2, D-Leu5] enkephalin (DADLE) induced dose-related effects that were weakly antagonized by ICI 174,864 and partly by low-dose naloxone. Thus the inhibition of intestinal transit induced by opioids may depend mainly on the interaction of the agonists at the mu-receptors, while the delta- receptors may play only a secondary role. DADLE agonist effects probably depend on interaction at mu-, delta- and at non-opioid receptors.

Original languageEnglish
Pages (from-to)520-523
Number of pages4
JournalNIDA research monograph
Volume75
Publication statusPublished - 1986

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delta Opioid Receptor
mu Opioid Receptor
Naloxone
D-Penicillamine (2,5)-Enkephalin
Ligands
Enkephalins
Charcoal
Morphine
Opioid Analgesics
Meals
Peptides
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Sbacchi, M., La Regina, A., Petrillo, P., & Tavani, A. (1986). The role of mu- and delta- opioid receptors on the intestinal propulsion in rats. NIDA research monograph, 75, 520-523.

The role of mu- and delta- opioid receptors on the intestinal propulsion in rats. / Sbacchi, M.; La Regina, A.; Petrillo, P.; Tavani, A.

In: NIDA research monograph, Vol. 75, 1986, p. 520-523.

Research output: Contribution to journalArticle

Sbacchi, M, La Regina, A, Petrillo, P & Tavani, A 1986, 'The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.', NIDA research monograph, vol. 75, pp. 520-523.
Sbacchi, M. ; La Regina, A. ; Petrillo, P. ; Tavani, A. / The role of mu- and delta- opioid receptors on the intestinal propulsion in rats. In: NIDA research monograph. 1986 ; Vol. 75. pp. 520-523.
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