The role of omega-3 fatty acids in developmental psychopathology: A systematic review on early psychosis, autism, and ADHD

Carlo Agostoni, Maria Nobile, Valentina Ciappolino, Giuseppe Delvecchio, Alessandra Tesei, Stefano Turolo, Alessandro Crippa, Alessandra Mazzocchi, Carlo A. Altamura, Paolo Brambilla

Research output: Contribution to journalReview article

Abstract

In this systematic review, we will consider and debate studies that have explored the effects of ω-3 polyunsaturated fatty acids (PUFAs) in three major, and somehow related, developmental psychiatric disorders: Autism, Attention Deficit and Hyperactivity disorder and Psychosis. The impact of ω-3 PUFAs on clinical symptoms and, if possible, brain trajectory in children and adolescents suffering from these illnesses will be reviewed and discussed, considering the biological plausibility of the effects of omega-3 fatty acids, together with their potential perspectives in the field. Heterogeneity in study designs will be discussed in the light of differences in results and interpretation of studies carried out so far.

Original languageEnglish
Article number2608
JournalInternational Journal of Molecular Sciences
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 4 2017

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Keywords

  • Attention deficit hyperactivity disorder (ADHD)
  • Autism
  • Docosahexaenoic acid (DHA)
  • Eicosapentaenoic acid (EPA)
  • First psychotic episode
  • Neurodevelopment
  • Omega-3
  • PUFAs
  • Ultra-high risk for psychosis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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