TY - CHAP
T1 - The role of Otx genes in progenitor domains of ventral midbrain
AU - Simeone, Antonio
AU - Puelles, Eduardo
AU - Acampora, Dario
AU - Omodei, Daniela
AU - Mancuso, Pietro
AU - Di Giovannantonio, Luca Giovanni
PY - 2009
Y1 - 2009
N2 - The mesencephalic dopaminergic (mesDA) neurons playa relevant role in the control of movement,behaviourand cognition. Indeedlossand/or abnormal development of mesDA neurons is responsiblefor Parkinson'sdiseaseas well as for addictive and psychiatric disorders. A wealth of information has been provided on gene functions involved in the molecular mechanism controlling identity, fate and survival of mesDA neurons. Collectively, these studies are contributing to a growing knowledge of the genetic networks required for proper mesDA development, thus disclosing new perspectives for therapeutic approaches of mesDA disorders. Here we will focus on the control exerted by Otx genesin early decisions regulating the differentiation of progenitors located in the ventral midbrain. In this context, the regulatory network involving Otx functional interactions with signalling molecules and transcription factors required to promote or prevent the development ofmesDA neurons will be analyzed in detail.
AB - The mesencephalic dopaminergic (mesDA) neurons playa relevant role in the control of movement,behaviourand cognition. Indeedlossand/or abnormal development of mesDA neurons is responsiblefor Parkinson'sdiseaseas well as for addictive and psychiatric disorders. A wealth of information has been provided on gene functions involved in the molecular mechanism controlling identity, fate and survival of mesDA neurons. Collectively, these studies are contributing to a growing knowledge of the genetic networks required for proper mesDA development, thus disclosing new perspectives for therapeutic approaches of mesDA disorders. Here we will focus on the control exerted by Otx genesin early decisions regulating the differentiation of progenitors located in the ventral midbrain. In this context, the regulatory network involving Otx functional interactions with signalling molecules and transcription factors required to promote or prevent the development ofmesDA neurons will be analyzed in detail.
UR - http://www.scopus.com/inward/record.url?scp=70349783913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349783913&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-0322-8_3
DO - 10.1007/978-1-4419-0322-8_3
M3 - Chapter
C2 - 19731548
AN - SCOPUS:70349783913
SN - 9781441903211
VL - 651
T3 - Advances in Experimental Medicine and Biology
SP - 36
EP - 46
BT - Advances in Experimental Medicine and Biology
ER -