The role of oxidative stress and membrane transport systems during endometriosis: A fresh look at a busy corner

Salvatore Giovanni Vitale, Stella Capriglione, Isabel Peterlunger, Valentina Lucia La Rosa, Amerigo Vitagliano, Marco Noventa, Gaetano Valenti, Fabrizio Sapia, Roberto Angioli, Salvatore Lopez, Giuseppe Sarpietro, Diego Rossetti, Gabriella Zito

Research output: Contribution to journalReview articlepeer-review


Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis. In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines. In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms-among which pain and infertility. The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms.

Original languageEnglish
Article number7924021
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology


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