The role of p-selectin in covid-19 coagulopathy: An updated review

Research output: Contribution to journalReview articlepeer-review

Abstract

In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that charac-terizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.

Original languageEnglish
Article number7942
Pages (from-to)1-12
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume22
Issue number15
DOIs
Publication statusPublished - Aug 1 2021

Keywords

  • COVID-19
  • P-selectin
  • SARS-CoV-2

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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