The role of p53 and pRB in apoptosis and cancer

Emma S. Hickman, M. Cristina Moroni, Kristian Helin

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitises cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 1 2002

ASJC Scopus subject areas

  • Genetics

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