TY - JOUR
T1 - The role of p53 and pRB in apoptosis and cancer
AU - Hickman, Emma S.
AU - Moroni, M. Cristina
AU - Helin, Kristian
PY - 2002/2/1
Y1 - 2002/2/1
N2 - Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitises cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.
AB - Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitises cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.
UR - http://www.scopus.com/inward/record.url?scp=0036467582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036467582&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(01)00265-9
DO - 10.1016/S0959-437X(01)00265-9
M3 - Article
C2 - 11790556
AN - SCOPUS:0036467582
VL - 12
SP - 60
EP - 66
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 1
ER -