The role of prefrontal cortex in verbal episodic memory: rTMS evidence

Marco Sandrini, Stefano F. Cappa, Simone Rossi, Paolo M. Rossini, Carlo Miniussi

Research output: Contribution to journalArticlepeer-review


Long-term, episodic memory processing is supposed to involve the prefrontal cortex asymmetrically. Here we investigate the role of the dorsolateral prefrontal cortex (DLPFC) in encoding and retrieval of semantically related or unrelated word pairs. Subjects were required to perform a task consisting of two parts: a study phase (encoding), in which word pairs were presented, and a test phase (retrieval), during which stimuli previously presented had to be recognized among other stimuli. Consistently with our previous findings using pictures, repetitive transcranial magnetic stimulation (rTMS) had a significant impact on episodic memory. The performance was significantly disrupted when rTMS was applied to the left or right DLPFC during encoding, and to the right DLPFC in retrieval, but only for unrelated word pairs. These results indicate that the nature of the material to be remembered interacts with the encoding-retrieval DLPFC asymmetry; moreover, the crucial role of DLPFC is evident only for novel stimuli.

Original languageEnglish
Pages (from-to)855-861
Number of pages7
JournalJournal of Cognitive Neuroscience
Issue number6
Publication statusPublished - Aug 15 2003

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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