The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

Lorenzo Bianchi, Alessandro Nini, Marco Bianchi, Giorgio Gandaglia, Nicola Fossati, Nazareno Suardi, Marco Moschini, Paolo Dell'Oglio, Riccardo Schiavina, Francesco Montorsi, Alberto Briganti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective: To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants: The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA

Original languageEnglish
JournalEuropean Urology
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Biochemical response
  • Cancer-specific mortality
  • Clinical recurrence
  • Lymph node invasion
  • Prostate cancer
  • PSA persistence
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology

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