The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

Lorenzo Bianchi; Alessandro Nini; Marco Bianchi; Giorgio Gandaglia; Nicola Fossati; Nazareno Suardi; Marco Moschini; Paolo Dell'Oglio; Riccardo Schiavina; Francesco Montorsi; Alberto Briganti

doi:10.1016/j.eururo.2015.12.010

The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

Lorenzo Bianchi, Alessandro Nini, Marco Bianchi, Giorgio Gandaglia, Nicola Fossati, Nazareno Suardi, Marco Moschini, Paolo Dell'Oglio, Riccardo Schiavina, Francesco Montorsi, Alberto Briganti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective: To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants: The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA

Original language	English
Journal	European Urology
DOIs	https://doi.org/10.1016/j.eururo.2015.12.010
Publication status	Accepted/In press - 2015

Keywords

Biochemical response
Cancer-specific mortality
Clinical recurrence
Lymph node invasion
Prostate cancer
PSA persistence
Radical prostatectomy

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2015.12.010

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Bianchi, L., Nini, A., Bianchi, M., Gandaglia, G., Fossati, N., Suardi, N., Moschini, M., Dell'Oglio, P., Schiavina, R., Montorsi, F., & Briganti, A. (Accepted/In press). The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients. European Urology. https://doi.org/10.1016/j.eururo.2015.12.010

The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients. / Bianchi, Lorenzo; Nini, Alessandro; Bianchi, Marco; Gandaglia, Giorgio; Fossati, Nicola; Suardi, Nazareno; Moschini, Marco; Dell'Oglio, Paolo; Schiavina, Riccardo; Montorsi, Francesco ; Briganti, Alberto.

In: European Urology, 2015.

Research output: Contribution to journal › Article › peer-review

Bianchi, L, Nini, A, Bianchi, M, Gandaglia, G, Fossati, N, Suardi, N, Moschini, M, Dell'Oglio, P, Schiavina, R, Montorsi, F & Briganti, A 2015, 'The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients', European Urology. https://doi.org/10.1016/j.eururo.2015.12.010

Bianchi, Lorenzo ; Nini, Alessandro ; Bianchi, Marco ; Gandaglia, Giorgio ; Fossati, Nicola ; Suardi, Nazareno ; Moschini, Marco ; Dell'Oglio, Paolo ; Schiavina, Riccardo ; Montorsi, Francesco ; Briganti, Alberto. / The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients. In: European Urology. 2015.

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title = "The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients",

abstract = "Background: A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective: To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants: The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA ",

keywords = "Biochemical response, Cancer-specific mortality, Clinical recurrence, Lymph node invasion, Prostate cancer, PSA persistence, Radical prostatectomy",

author = "Lorenzo Bianchi and Alessandro Nini and Marco Bianchi and Giorgio Gandaglia and Nicola Fossati and Nazareno Suardi and Marco Moschini and Paolo Dell'Oglio and Riccardo Schiavina and Francesco Montorsi and Alberto Briganti",

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doi = "10.1016/j.eururo.2015.12.010",

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journal = "European Urology",

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T1 - The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

AU - Bianchi, Lorenzo

AU - Nini, Alessandro

AU - Bianchi, Marco

AU - Gandaglia, Giorgio

AU - Fossati, Nicola

AU - Suardi, Nazareno

AU - Moschini, Marco

AU - Dell'Oglio, Paolo

AU - Schiavina, Riccardo

AU - Montorsi, Francesco

AU - Briganti, Alberto

PY - 2015

Y1 - 2015

N2 - Background: A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective: To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants: The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA

AB - Background: A complete biochemical response (BR) immediately after surgery could be considered an indicator of optimal cancer control after radical prostatectomy (RP). Objective: To evaluate the prognostic value of early postoperative prostate-specific antigen (PSA) levels after RP in patients with lymph node invasion (LNI). Design, setting, and participants: The study included 319 prostate cancer patients with LNI who were treated with RP and extended pelvic lymph node dissection (ePLND) at a single institution between 1998 and 2013. All men had complete clinical, pathologic, and follow-up data, including PSA value at 6 wk after surgery. Patients were divided into two groups according to PSA value at 6 wk after surgery: complete BR (PSA

KW - Biochemical response

KW - Cancer-specific mortality

KW - Clinical recurrence

KW - Lymph node invasion

KW - Prostate cancer

KW - PSA persistence

KW - Radical prostatectomy

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The Role of Prostate-specific Antigen Persistence After Radical Prostatectomy for the Prediction of Clinical Progression and Cancer-specific Mortality in Node-positive Prostate Cancer Patients

Abstract

Keywords

ASJC Scopus subject areas

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