The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: A systematic review and meta-analysis

Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido, Carlo Alviggi

Research output: Contribution to journalReview article

Abstract

Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

Original languageEnglish
Article number18
JournalReproductive Biology and Endocrinology
Volume17
Issue number1
DOIs
Publication statusPublished - Feb 6 2019

Fingerprint

Ovulation Induction
Pregnancy Rate
Oocytes
Meta-Analysis
Odds Ratio
Spontaneous Abortion
Gonadotropins
MEDLINE
Language
Clinical Trials
Databases
Weights and Measures

Keywords

  • Assisted reproductive technologies
  • Hypo-responders
  • In vitro fertilization
  • LH
  • Ovulation induction
  • Recombinant LH

ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

The role of recombinant LH in women with hypo-response to controlled ovarian stimulation : A systematic review and meta-analysis. / Conforti, Alessandro; Esteves, Sandro C.; Di Rella, Francesca; Strina, Ida; De Rosa, Pasquale; Fiorenza, Alessia; Zullo, Fulvio; De Placido, Giuseppe; Alviggi, Carlo.

In: Reproductive Biology and Endocrinology, Vol. 17, No. 1, 18, 06.02.2019.

Research output: Contribution to journalReview article

Conforti, Alessandro ; Esteves, Sandro C. ; Di Rella, Francesca ; Strina, Ida ; De Rosa, Pasquale ; Fiorenza, Alessia ; Zullo, Fulvio ; De Placido, Giuseppe ; Alviggi, Carlo. / The role of recombinant LH in women with hypo-response to controlled ovarian stimulation : A systematic review and meta-analysis. In: Reproductive Biology and Endocrinology. 2019 ; Vol. 17, No. 1.
@article{88cd3e6295ba44dd8e64eabfb9ae922c,
title = "The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: A systematic review and meta-analysis",
abstract = "Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.",
keywords = "Assisted reproductive technologies, Hypo-responders, In vitro fertilization, LH, Ovulation induction, Recombinant LH",
author = "Alessandro Conforti and Esteves, {Sandro C.} and {Di Rella}, Francesca and Ida Strina and {De Rosa}, Pasquale and Alessia Fiorenza and Fulvio Zullo and {De Placido}, Giuseppe and Carlo Alviggi",
year = "2019",
month = "2",
day = "6",
doi = "10.1186/s12958-019-0460-4",
language = "English",
volume = "17",
journal = "Reproductive Biology and Endocrinology",
issn = "1477-7827",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - The role of recombinant LH in women with hypo-response to controlled ovarian stimulation

T2 - A systematic review and meta-analysis

AU - Conforti, Alessandro

AU - Esteves, Sandro C.

AU - Di Rella, Francesca

AU - Strina, Ida

AU - De Rosa, Pasquale

AU - Fiorenza, Alessia

AU - Zullo, Fulvio

AU - De Placido, Giuseppe

AU - Alviggi, Carlo

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

AB - Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

KW - Assisted reproductive technologies

KW - Hypo-responders

KW - In vitro fertilization

KW - LH

KW - Ovulation induction

KW - Recombinant LH

UR - http://www.scopus.com/inward/record.url?scp=85061136515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061136515&partnerID=8YFLogxK

U2 - 10.1186/s12958-019-0460-4

DO - 10.1186/s12958-019-0460-4

M3 - Review article

C2 - 30728019

AN - SCOPUS:85061136515

VL - 17

JO - Reproductive Biology and Endocrinology

JF - Reproductive Biology and Endocrinology

SN - 1477-7827

IS - 1

M1 - 18

ER -