The Role of Secretory IgA and Complement in IgA Nephropathy

Beatrijs D. Oortwijn, Jan Willem Eijgenraam, Maria P. Rastaldi, Anja Roos, Mohamed R. Daha, Cees van Kooten

Research output: Contribution to journalArticlepeer-review

Abstract

IgA nephropathy (IgAN) is characterized by glomerular deposition of IgA, often together with complement components. This deposited IgA is mainly polymeric in nature. Although early studies suggested a role for local complement activation in the development of glomerular injury in IgAN, recent attention has focused on the involvement of the lectin pathway of complement activation in the progression of renal disease in IgAN. In addition, we have found that glomerular secretory IgA deposition may be one of the initiators of local complement activation in the kidney. In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalSeminars in Nephrology
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • antigen-specific IgA
  • complement activation
  • IgA nephropathy
  • mannose binding lectin
  • Secretory IgA

ASJC Scopus subject areas

  • Nephrology

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