The role of serum carcinoembryonic antigen (CEA) in the management of patients with colorectal carcinoma

The experience of the Istituto Tumori of Milan

E. Seregni, E. Bombardieri, A. Bogni, F. Crippa, E. De Jager, G. L. Buraggi

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10 Citations (Scopus)

Abstract

CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61% showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases false-positive results.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalInternational Journal of Biological Markers
Volume7
Issue number3
Publication statusPublished - 1992

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Carcinoembryonic Antigen
Colorectal Neoplasms
Serum
Tumors
Recurrence

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

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abstract = "CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61{\%} showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases false-positive results.",
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AU - Bogni, A.

AU - Crippa, F.

AU - De Jager, E.

AU - Buraggi, G. L.

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AB - CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61% showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases false-positive results.

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