The role of six biomarkers in diagnosis of hemophilic arthropathy: review of the literature

ADVANCES IN MUSCULOSKELETAL DISEASES AND INFECTIONS - SOTIMI 2019:

Research output: Contribution to journalReview articlepeer-review

Abstract

The aim of our narrative review of the literature is to identify the role of six important biomarkers: synovial fluid thrombomodulin, fibroblast-like synoviocytes, synovial tissue growth factor , vascular endothelial growth factor in synovium and peripheral blood, urinary C-terminal telopeptide of type II collagen, and synovial fluid tumor necrosis factor alpha. These urinary, serum and synovial biomarkers illustrated should be evaluated in patients with hemophilic arthropathy for early diagnosis of hemophilic arthropathy, because they have important implications in the development of arthrofibrosis, altered inflammatory response and bleeding. Moreover, better knowledge of their biological activity is important to identify possible new biological treatment options.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalJournal of Biological Regulators and Homeostatic Agents
Volume34
Issue number3
Publication statusPublished - May 1 2020

Keywords

  • biomarkers
  • hemarthrosis
  • hemophilia
  • hemophilic arthropathy
  • synovitis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

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