Ruolo di alcuni micronutrienti (vit. A, vit. E, GSH-Px) nell'evoluzione dell'infezione da HPV

Translated title of the contribution: The role of some micronutrients in the evolution of HPV infection

M. Atlante, L. Mariani, M. Luci, E. Carico, F. Diotallevi, A. Iacovelli, C. Vincenzoni

Research output: Contribution to journalArticlepeer-review


Background. Over the past few years a series of research projects has shown that the scant or deficient immune response in HIV infection may be secondary to reduced cell resistance and/or the uncontrolled formation of free radicals. In line with these findings, subjects with HIV infection present a deficit of polyunsaturated fatty acids (the prncipal components of cell membranes) and many antioxidating substances, like Vitamin E and glutathione peroxidase. The high incidence of heterosexual transmission of HIV has now shown the close correlation between HIV infection and HPV infection. By analogy, we wanted to ascertain wheter these deficits were also present in subjects with HPV infection and dysplastic and neoplastic lesions of the uterine cervix. Published data confirm that a HPV-positive subject has an increased risk, ranging from 40 to 200%, of contracting HIV infection. Methods. Eighty women wuith HPV infection of the genital tract, at various stages. Blood levels of vitamin E and polyunsaturated fatty acids were measured using gas-chromatography; glutathione was assayed using the spectrophotometric technique. Results. The alternation of the aforesaid parameters is correlated to the progress of infection and increases with the severity of lesions; Statistically significant data were recorded by comparing the group with condylomatosis with patients diagnosed with cervical carcinoma (p

Translated title of the contributionThe role of some micronutrients in the evolution of HPV infection
Original languageItalian
Pages (from-to)179-183
Number of pages5
JournalMinerva Ginecologica
Issue number2
Publication statusPublished - Apr 2002

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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