Znaczenie spontanicznej wrażliwości baroreceptorów w przewidywaniu późnych nawrotów migotania przedsionków

Translated title of the contribution: The role of spontaneous baroreflex sensitivity in predicting late atrial fibrillation recurrence

Katarzyna Styczkiewicz, Mario Facchini, Giovanni Battista Perego, Grzegorz Bilo, Danuta Czarnecka, Kalina Kawecka-Jaszcz, Gianfranco Parati

Research output: Contribution to journalArticle

Abstract

Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.

Original languagePolish
Pages (from-to)483-497
Number of pages15
JournalNadcisnienie Tetnicze
Volume11
Issue number6
Publication statusPublished - 2007

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Baroreflex
Atrial Fibrillation
Recurrence
Blood Pressure
History

Keywords

  • Atrial fibrillation
  • Autonomic nervous system
  • Baroreflex sensitivity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Znaczenie spontanicznej wrażliwości baroreceptorów w przewidywaniu późnych nawrotów migotania przedsionków. / Styczkiewicz, Katarzyna; Facchini, Mario; Perego, Giovanni Battista; Bilo, Grzegorz; Czarnecka, Danuta; Kawecka-Jaszcz, Kalina; Parati, Gianfranco.

In: Nadcisnienie Tetnicze, Vol. 11, No. 6, 2007, p. 483-497.

Research output: Contribution to journalArticle

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title = "Znaczenie spontanicznej wrażliwości baroreceptor{\'o}w w przewidywaniu p{\'o}źnych nawrot{\'o}w migotania przedsionk{\'o}w",
abstract = "Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3{\%}) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.",
keywords = "Atrial fibrillation, Autonomic nervous system, Baroreflex sensitivity",
author = "Katarzyna Styczkiewicz and Mario Facchini and Perego, {Giovanni Battista} and Grzegorz Bilo and Danuta Czarnecka and Kalina Kawecka-Jaszcz and Gianfranco Parati",
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T1 - Znaczenie spontanicznej wrażliwości baroreceptorów w przewidywaniu późnych nawrotów migotania przedsionków

AU - Styczkiewicz, Katarzyna

AU - Facchini, Mario

AU - Perego, Giovanni Battista

AU - Bilo, Grzegorz

AU - Czarnecka, Danuta

AU - Kawecka-Jaszcz, Kalina

AU - Parati, Gianfranco

PY - 2007

Y1 - 2007

N2 - Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.

AB - Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.

KW - Atrial fibrillation

KW - Autonomic nervous system

KW - Baroreflex sensitivity

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