Abstract
Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.
| Original language | Polish |
|---|---|
| Pages (from-to) | 483-497 |
| Number of pages | 15 |
| Journal | Nadcisnienie Tetnicze |
| Volume | 11 |
| Issue number | 6 |
| Publication status | Published - 2007 |
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Keywords
- Atrial fibrillation
- Autonomic nervous system
- Baroreflex sensitivity
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Znaczenie spontanicznej wrażliwości baroreceptorów w przewidywaniu późnych nawrotów migotania przedsionków. / Styczkiewicz, Katarzyna; Facchini, Mario; Perego, Giovanni Battista; Bilo, Grzegorz; Czarnecka, Danuta; Kawecka-Jaszcz, Kalina; Parati, Gianfranco.
In: Nadcisnienie Tetnicze, Vol. 11, No. 6, 2007, p. 483-497.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Znaczenie spontanicznej wrażliwości baroreceptorów w przewidywaniu późnych nawrotów migotania przedsionków
AU - Styczkiewicz, Katarzyna
AU - Facchini, Mario
AU - Perego, Giovanni Battista
AU - Bilo, Grzegorz
AU - Czarnecka, Danuta
AU - Kawecka-Jaszcz, Kalina
AU - Parati, Gianfranco
PY - 2007
Y1 - 2007
N2 - Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.
AB - Background: Changes in sympathetic and vagal neural regulatory mechanisms play a crucial role in alterations of cardiac electrical properties and in promoting the occurrence of atrial fibrillation (AF). Spontaneous baroreflex sensitivity (BRS) is useful diagnostic tool for assessment of autonomic cardiovascular regulation however until now there have been no data concerning its role as a trigger of AF onset. Aim of the present study was assessment of baroreflex function in patients with and without late AF recurrence and identification of independent predictors of late AF recurrence during 6-month observation. Material and methods: The study population consisted of 60 patients who experienced at least one AF episode during the last 3 months. All subjects underwent beat-to-beat blood pressure (BP) monitoring. Baroreflex function was assessed in the frequency domain BRS (alpha coefficient, modulus of transfer function-H), and in the time domain (sequence technique). The study end point involved late recurrence of AF or the end of 6-month follow-up. Results: During the follow-up 29 (48.3%) patients experienced late AF recurrence. The group with AF recurrence as compared with the sinus rhythm maintenance group was characterized by increased spontaneous BRS assessed using all 3 methods (alpha LF: 7.7 ± 4.1 vs. 4.8 ± 1.8 ms/mm Hg, p = 0.002; alpha HF: 22.0 ± 17.2 vs. 10.7 ± 5.0 ms/mm Hg, p = 0.002; H-LF: 6.0 ± 3.3 vs. 3.8 ± 1.5 ms/mm Hg, p = 0.002; H-HF: 17.3 ± 13.4 vs. 8.6 ± 3.9 ms/mm Hg, p = 0.002; weighted sequence method - wSeq 9.5 ± 4.2 vs. 5.8 ± 3.3, p = 0.001). The Cox regression analysis revealed that independent predictors of AF were only BRS indices and AF duration history. Conclusions: Patients with late atrial fibrillation recurrence are characterized by augmented parasympathetic modulation. Indices of spontaneous baroreflex sensitivity are independent predictors of late atrial fibrillation recurrence. The noninvasive method of spontaneous baroreflex sensitivity assessment based on beat-to-beat blood pressure monitoring appears to have a clinical value as a promising method for early identification of patients at higher AF recurrence rate and thus enabling prevention of further episodes.
KW - Atrial fibrillation
KW - Autonomic nervous system
KW - Baroreflex sensitivity
UR - http://www.scopus.com/inward/record.url?scp=39449108639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39449108639&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:39449108639
VL - 11
SP - 483
EP - 497
JO - Nadcisnienie Tetnicze
JF - Nadcisnienie Tetnicze
SN - 1428-5851
IS - 6
ER -