TY - JOUR
T1 - The role of surgery in recurrent endometrial cancer
AU - Zanfagnin, Valentina
AU - Ferrero, Annamaria
AU - Biglia, Nicoletta
AU - Aletti, Giovanni
AU - Gill, Sarah E.
AU - Makdisi, Peter B.
AU - Multinu, Francesco
AU - Mariani, Andrea
PY - 2016/7/2
Y1 - 2016/7/2
N2 - ABSTRACT: Introduction: Endometrial cancer is a common gynecologic malignancy in the United States, and the recurrence rate depends on the disease stage at diagnosis. Recurrence can affect several areas and follow different patterns. Areas covered: The role of surgery at the time of recurrence is not clearly defined. In this review, we fully describe the current evidence available. In particular, we describe how surgical treatment might be recommended for 1) vaginal or pelvic recurrences; 2) retroperitoneal or localized intra-abdominal recurrence, when a maximal cytoreductive effort is more likely to be successful; or 3) isolated distant recurrences when microscopically tumor-free margins can be achieved. Expert commentary: Cases should be evaluated individually, considering factors such as comorbidities, risks of intervention, and impact of treatment on quality of life.
AB - ABSTRACT: Introduction: Endometrial cancer is a common gynecologic malignancy in the United States, and the recurrence rate depends on the disease stage at diagnosis. Recurrence can affect several areas and follow different patterns. Areas covered: The role of surgery at the time of recurrence is not clearly defined. In this review, we fully describe the current evidence available. In particular, we describe how surgical treatment might be recommended for 1) vaginal or pelvic recurrences; 2) retroperitoneal or localized intra-abdominal recurrence, when a maximal cytoreductive effort is more likely to be successful; or 3) isolated distant recurrences when microscopically tumor-free margins can be achieved. Expert commentary: Cases should be evaluated individually, considering factors such as comorbidities, risks of intervention, and impact of treatment on quality of life.
KW - Endometrial neoplasm
KW - Intraoperative radiation therapy
KW - Metastases
KW - Quality of life
KW - Secondary cytoreductive surgery
UR - http://www.scopus.com/inward/record.url?scp=84976594868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976594868&partnerID=8YFLogxK
U2 - 10.1080/14737140.2016.1190650
DO - 10.1080/14737140.2016.1190650
M3 - Review article
AN - SCOPUS:84976594868
VL - 16
SP - 741
EP - 750
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 7
ER -