The role of T cells in drug reaction

Andrea Cavani, Ornella De Pità

Research output: Contribution to journalArticlepeer-review


T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and permitted the recognition of T cell-mediated cytotoxicity against drug-loaded resident cells as a major mechanism of tissue damage.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalCurrent Allergy and Asthma Reports
Issue number1
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Medicine(all)


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