The role of T cells in drug reaction

Andrea Cavani; Ornella De Pità

doi:10.1007/s11882-006-0005-8

The role of T cells in drug reaction

Andrea Cavani, Ornella De Pità

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and permitted the recognition of T cell-mediated cytotoxicity against drug-loaded resident cells as a major mechanism of tissue damage.

Original language	English
Pages (from-to)	20-24
Number of pages	5
Journal	Current Allergy and Asthma Reports
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/s11882-006-0005-8
Publication status	Published - Feb 2006

ASJC Scopus subject areas

Medicine(all)

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10.1007/s11882-006-0005-8

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abstract = "T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and permitted the recognition of T cell-mediated cytotoxicity against drug-loaded resident cells as a major mechanism of tissue damage.",

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The role of T cells in drug reaction

Abstract

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