Abstract
T cells are major protagonists of immune-mediated adverse drug eruptions. Immunohistochemical observation as well as isolation and functional characterization of T cells infiltrating the affected tissues provided new insights into the pathomechanisms of the diverse clinical manifestations of drug hypersensitivity, and permitted the recognition of T cell-mediated cytotoxicity against drug-loaded resident cells as a major mechanism of tissue damage.
Original language | English |
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Pages (from-to) | 20-24 |
Number of pages | 5 |
Journal | Current Allergy and Asthma Reports |
Volume | 6 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2006 |
ASJC Scopus subject areas
- Medicine(all)