Drugs are frequently responsible for hypersensitivity reactions, which vary greatly in their clinical appearance and severity, and involve the skin in most cases. T cells play a key role in the development of drug hypersensitivity reactions, either as major effector cells responsible for the tissue damage, or as orchestrators of B cell activity and IgE switching. T cell mediated cytotoxicity, due to granule exocytosis or Fas-Fas ligand interactions, is the most important pathogenetic mechanism in delayed hypersensitivity to drugs. Intervention of distinct T cell subsets, eg CD4+ versus CD8 + T cells, may explain the extreme heterogeneicity of the clinical manifestation of drug adverse reactions.
|Translated title of the contribution||The role of T lymphocytes in drug hypersensitivity reactions|
|Number of pages||3|
|Journal||Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale|
|Publication status||Published - Sep 2005|
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