Il ruolo dei linfociti T nelle reazioni di ipersensibilità ai farmaci

Translated title of the contribution: The role of T lymphocytes in drug hypersensitivity reactions

Andrea Cavani

Research output: Contribution to journalArticle

Abstract

Drugs are frequently responsible for hypersensitivity reactions, which vary greatly in their clinical appearance and severity, and involve the skin in most cases. T cells play a key role in the development of drug hypersensitivity reactions, either as major effector cells responsible for the tissue damage, or as orchestrators of B cell activity and IgE switching. T cell mediated cytotoxicity, due to granule exocytosis or Fas-Fas ligand interactions, is the most important pathogenetic mechanism in delayed hypersensitivity to drugs. Intervention of distinct T cell subsets, eg CD4+ versus CD8 + T cells, may explain the extreme heterogeneicity of the clinical manifestation of drug adverse reactions.

Original languageItalian
Pages (from-to)132-134
Number of pages3
JournalAnnali Italiani di Dermatologia Allergologica Clinica e Sperimentale
Volume59
Issue number3
Publication statusPublished - Sep 2005

Fingerprint

Drug Hypersensitivity
T-Lymphocytes
Fas Ligand Protein
Exocytosis
Delayed Hypersensitivity
T-Lymphocyte Subsets
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Immunoglobulin E
Hypersensitivity
B-Lymphocytes
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Il ruolo dei linfociti T nelle reazioni di ipersensibilità ai farmaci. / Cavani, Andrea.

In: Annali Italiani di Dermatologia Allergologica Clinica e Sperimentale, Vol. 59, No. 3, 09.2005, p. 132-134.

Research output: Contribution to journalArticle

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