The Role of the Cerebellum in Multiple Sclerosis - 150 years after Charcot

MAGNIMS study group

Research output: Contribution to journalReview article

Abstract

Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

Original languageEnglish
JournalNeuroscience and Biobehavioral Reviews
DOIs
Publication statusE-pub ahead of print - Feb 22 2018

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Cerebellum
Multiple Sclerosis
Magnetic Resonance Imaging
Pathology
Technology

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The Role of the Cerebellum in Multiple Sclerosis - 150 years after Charcot. / MAGNIMS study group.

In: Neuroscience and Biobehavioral Reviews, 22.02.2018.

Research output: Contribution to journalReview article

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title = "The Role of the Cerebellum in Multiple Sclerosis - 150 years after Charcot",
abstract = "Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.",
author = "{MAGNIMS study group} and Katrin Parmar and Christine Stadelmann and Rocca, {Maria A} and Dawn Langdon and Egidio D'Angelo and Marcus D'Souza and Jessica Burggraaff and Christiane Wegner and Jaume Sastre-Garriga and Alonso Barrantes-Freer and Jonas Dorn and Uitdehaag, {Bernard M J} and Xavier Montalban and Jens Wuerfel and Christian Enzinger and Alex Rovira and Mar Tintore and Massimo Filippi and Ludwig Kappos and Till Sprenger",
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AU - MAGNIMS study group

AU - Parmar, Katrin

AU - Stadelmann, Christine

AU - Rocca, Maria A

AU - Langdon, Dawn

AU - D'Angelo, Egidio

AU - D'Souza, Marcus

AU - Burggraaff, Jessica

AU - Wegner, Christiane

AU - Sastre-Garriga, Jaume

AU - Barrantes-Freer, Alonso

AU - Dorn, Jonas

AU - Uitdehaag, Bernard M J

AU - Montalban, Xavier

AU - Wuerfel, Jens

AU - Enzinger, Christian

AU - Rovira, Alex

AU - Tintore, Mar

AU - Filippi, Massimo

AU - Kappos, Ludwig

AU - Sprenger, Till

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/2/22

Y1 - 2018/2/22

N2 - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

AB - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

U2 - 10.1016/j.neubiorev.2018.02.012

DO - 10.1016/j.neubiorev.2018.02.012

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JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

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