The role of the endothelium in hemolytic uremic syndrome

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Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.

Original languageEnglish
JournalJournal of Nephrology
Issue number4 SUPPL.
Publication statusPublished - 2001


  • Complement
  • Endothelium
  • Leukocytes
  • Platelets
  • Verotoxin

ASJC Scopus subject areas

  • Nephrology


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