Abstract
Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.
| Original language | English |
|---|---|
| Journal | Journal of Nephrology |
| Volume | 14 |
| Issue number | 4 SUPPL. |
| Publication status | Published - 2001 |
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Keywords
- Complement
- Endothelium
- Leukocytes
- Platelets
- Verotoxin
ASJC Scopus subject areas
- Nephrology
Cite this
The role of the endothelium in hemolytic uremic syndrome. / Zoja, Carla.
In: Journal of Nephrology, Vol. 14, No. 4 SUPPL., 2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of the endothelium in hemolytic uremic syndrome
AU - Zoja, Carla
PY - 2001
Y1 - 2001
N2 - Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.
AB - Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.
KW - Complement
KW - Endothelium
KW - Leukocytes
KW - Platelets
KW - Verotoxin
UR - http://www.scopus.com/inward/record.url?scp=0035524167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035524167&partnerID=8YFLogxK
M3 - Article
C2 - 11798147
AN - SCOPUS:0035524167
VL - 14
JO - Journal of Nephrology
JF - Journal of Nephrology
SN - 1121-8428
IS - 4 SUPPL.
ER -