The role of the endothelium in hemolytic uremic syndrome

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.

Original languageEnglish
JournalJournal of Nephrology
Volume14
Issue number4 SUPPL.
Publication statusPublished - 2001

Fingerprint

Hemolytic-Uremic Syndrome
Endothelium
Shiga-Toxigenic Escherichia coli
Escherichia coli Infections
Platelet Activation
Acute Kidney Injury
Thrombosis
Leukocytes
Kidney
Wounds and Injuries
Infection

Keywords

  • Complement
  • Endothelium
  • Leukocytes
  • Platelets
  • Verotoxin

ASJC Scopus subject areas

  • Nephrology

Cite this

The role of the endothelium in hemolytic uremic syndrome. / Zoja, Carla.

In: Journal of Nephrology, Vol. 14, No. 4 SUPPL., 2001.

Research output: Contribution to journalArticle

@article{57712756810448caa562ed2b2ea74bc2,
title = "The role of the endothelium in hemolytic uremic syndrome",
abstract = "Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.",
keywords = "Complement, Endothelium, Leukocytes, Platelets, Verotoxin",
author = "Carla Zoja",
year = "2001",
language = "English",
volume = "14",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Springer International Publishing",
number = "4 SUPPL.",

}

TY - JOUR

T1 - The role of the endothelium in hemolytic uremic syndrome

AU - Zoja, Carla

PY - 2001

Y1 - 2001

N2 - Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.

AB - Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ rnicrovascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.

KW - Complement

KW - Endothelium

KW - Leukocytes

KW - Platelets

KW - Verotoxin

UR - http://www.scopus.com/inward/record.url?scp=0035524167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035524167&partnerID=8YFLogxK

M3 - Article

C2 - 11798147

AN - SCOPUS:0035524167

VL - 14

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 4 SUPPL.

ER -