The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis

Domenico Bonamonte; Angela Filoni; Michelangelo Vestita; Paolo Romita; Caterina Foti; Gianni Angelini

doi:10.1155/2019/2450605

The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis

Domenico Bonamonte, Angela Filoni, Michelangelo Vestita, Paolo Romita, Caterina Foti, Gianni Angelini

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Review article › peer-review

Abstract

Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence of AD in developing countries is gradually getting close to that of developed ones, in which AD affects 20% of the paediatric population. Such an increment, associated with significant variations in prevalence among the various countries, underlines the importance of environmental factors in the disease onset. Among these, great importance is given to hygiene, intestinal microbiota, exposure to bacterial endotoxins, outdoor living with contact to animals, atmospheric pollution, weather, and diet. Genetic (alteration of the skin barrier function) as well as immunologic factors concur with the environmental ones. Only the systematical study of all these elements can best elucidate AD epidemiology.

Original language	English
Article number	2450605
Journal	BioMed Research International
Volume	2019
DOIs	https://doi.org/10.1155/2019/2450605
Publication status	Published - Jan 1 2019

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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title = "The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis",

abstract = "Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence of AD in developing countries is gradually getting close to that of developed ones, in which AD affects 20% of the paediatric population. Such an increment, associated with significant variations in prevalence among the various countries, underlines the importance of environmental factors in the disease onset. Among these, great importance is given to hygiene, intestinal microbiota, exposure to bacterial endotoxins, outdoor living with contact to animals, atmospheric pollution, weather, and diet. Genetic (alteration of the skin barrier function) as well as immunologic factors concur with the environmental ones. Only the systematical study of all these elements can best elucidate AD epidemiology.",

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AU - Bonamonte, Domenico

AU - Filoni, Angela

AU - Vestita, Michelangelo

AU - Romita, Paolo

AU - Foti, Caterina

AU - Angelini, Gianni

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AB - Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence of AD in developing countries is gradually getting close to that of developed ones, in which AD affects 20% of the paediatric population. Such an increment, associated with significant variations in prevalence among the various countries, underlines the importance of environmental factors in the disease onset. Among these, great importance is given to hygiene, intestinal microbiota, exposure to bacterial endotoxins, outdoor living with contact to animals, atmospheric pollution, weather, and diet. Genetic (alteration of the skin barrier function) as well as immunologic factors concur with the environmental ones. Only the systematical study of all these elements can best elucidate AD epidemiology.

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