The role of the extracellular matrix in primary myelofibrosis

O. Leiva, S. K. Ng, S. Chitalia, A. Balduini, S. Matsuura, K. Ravid

Research output: Contribution to journalReview articlepeer-review


Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in the progression of BM fibrosis. This review surveys ECM proteins contributors of PMF, and highlights how better understanding of the control of the ECM within the BM niche may lead to combined therapeutic options in PMF.

Original languageEnglish
Article numbere525
JournalBlood Cancer Journal
Issue number2
Publication statusPublished - Feb 3 2017

ASJC Scopus subject areas

  • Hematology
  • Oncology


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