The role of the immune system in the physiopathology of osteoporosis

Valentina Cagnetta, Vittorio Patella

Research output: Contribution to journalArticlepeer-review


The close anatomical relationship between the immune system, estrogen deficiency and bone loss has been recognized for centuries but the existence of a functional relationship has emerged only recently. The role of the immune system in the development of senile osteoporosis, which arises primarily through the effects of estrogen deficiency and secondary hyperparathyroidism, is slowly being unraveled. This review focuses the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and their activity. The under standing of the interplay of inflammation and osteoclast can lead to the development of new drugs for prevention and treatment of bone loss.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalClinical Cases in Mineral and Bone Metabolism
Issue number2
Publication statusPublished - May 2012


  • B cells
  • Cytokines
  • Immune system
  • Osteoclast
  • Osteoporosis
  • T cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine


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