The effects of sulpiride isomers injected into the nucleus accumbens on the anti-immobility activity of desipramine in rats were studied to clarify the role of dopamine receptors. (-)-Sulpiride 100 ng/0.5 μ1 injected bilaterally into the nucleus accumbens 5 min before testing reduced the effect of a 7-day treatment with 10 mg/kg per day desipramine in the swimming test but 5 μg/0.5 μl (+)-sulpiride injected in the same area had no effect. Fluphenazine, 5 μg/0.5 μl, or 6-hydroxydopamine-induced depletion of dopamine in the nucleus accumbens also reduced the anti-immobility effect of desipramine. The data further support the hypothesis that dopamine transmission in the nucleus accumbens has a permissive role in the effect of desipramine in the forced swimming test.
- (-) Sulpiride
- Forced swimming test
- Nucleus accumbens
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience