The role of the mesolimbic dopaminergic system in the despramine effect in the forced swimming test

Luigi Cervo, Giuliano Grignaschi, Rosario Samanin

Research output: Contribution to journalArticle

Abstract

The effects of sulpiride isomers injected into the nucleus accumbens on the anti-immobility activity of desipramine in rats were studied to clarify the role of dopamine receptors. (-)-Sulpiride 100 ng/0.5 μ1 injected bilaterally into the nucleus accumbens 5 min before testing reduced the effect of a 7-day treatment with 10 mg/kg per day desipramine in the swimming test but 5 μg/0.5 μl (+)-sulpiride injected in the same area had no effect. Fluphenazine, 5 μg/0.5 μl, or 6-hydroxydopamine-induced depletion of dopamine in the nucleus accumbens also reduced the anti-immobility effect of desipramine. The data further support the hypothesis that dopamine transmission in the nucleus accumbens has a permissive role in the effect of desipramine in the forced swimming test.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalEuropean Journal of Pharmacology
Volume178
Issue number1
DOIs
Publication statusPublished - Mar 13 1990

Keywords

  • (-) Sulpiride
  • (Rat)
  • Desipramine
  • Fluphenazine
  • Forced swimming test
  • Nucleus accumbens

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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