The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism

Vincenzo Marzolla, Andrea Armani, Maria Christina Zennaro, Francesca Cinti, Caterina Mammi, Andrea Fabbri, Giuseppe M C Rosano, Massimiliano Caprio

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Aldosterone controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor which regulates critical genes controlling salt and water homeostasis in the kidney. In recent years, inappropriate MR activation has been shown to trigger deleterious responses in various tissues, including vessels, heart and brain, hence promoting vascular inflammation, cardiovascular remodeling, endothelial dysfunction, and oxidative stress. Moreover, epidemiological studies have shown a clear association between aldosterone levels and the incidence of metabolic syndrome. In particular, recent work has revealed functional MRs in adipose tissue, where they mediate the effects of aldosterone and glucocorticoids, displaying important and specific functions involving adipose differentiation, expansion and proinflammatory capacity. This recent evidence finally moved MR out of the shadow of the glucocorticoid receptor (GR), which had previously been considered the only player mediating corticosteroid action in adipose tissue. This has opened a new era of research focusing on the complexity and selectivity of MR function in adipocyte biology.The aim of this review is to summarize the latest concepts on the role of MR in white and brown adipocytes, and to discuss the potential benefits of tissue-selective MR blockade in the treatment of obesity and metabolic syndrome.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume350
Issue number2
DOIs
Publication statusPublished - Mar 24 2012

Fingerprint

Mineralocorticoid Receptors
Adipocytes
Metabolism
Fats
Aldosterone
Tissue
Adipose Tissue
White Adipocytes
Brown Adipocytes
Oxidative stress
Glucocorticoid Receptors
Blood pressure
Glucocorticoids
Blood Vessels
Epidemiologic Studies
Brain
Adrenal Cortex Hormones
Oxidative Stress
Homeostasis
Transcription Factors

Keywords

  • Adipocyte
  • Adipose tissue
  • Metabolic syndrome
  • Mineralocorticoid receptor

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism. / Marzolla, Vincenzo; Armani, Andrea; Zennaro, Maria Christina; Cinti, Francesca; Mammi, Caterina; Fabbri, Andrea; Rosano, Giuseppe M C; Caprio, Massimiliano.

In: Molecular and Cellular Endocrinology, Vol. 350, No. 2, 24.03.2012, p. 281-288.

Research output: Contribution to journalArticle

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