The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia

Jacopo A. Vitale, Matteo Bonato, Antonio La Torre, Giuseppe Banfi

Research output: Contribution to journalReview article

Abstract

The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia. Therefore, the aim of this review is to present the latest findings demonstrating how circadian rhythms in skeletal muscle are important for maintenance of the cellular physiology, metabolism and function of skeletal muscle. Moreover, we will present the current knowledge about the tissue-specific functions of the molecular clock in skeletal muscle.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number17
DOIs
Publication statusPublished - Sep 3 2019

Fingerprint

Sarcopenia
skeletal muscle
clocks
Muscle
Clocks
Skeletal Muscle
circadian rhythms
Growth
metabolism
Circadian Rhythm
maintenance
Metabolism
Maintenance
Circadian Clocks
phenotype
Molecular Models
physiology
muscles
Physiology
health

Keywords

  • ageing
  • function
  • muscle
  • orthopaedics
  • Sarcopenia
  • strength

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia. / Vitale, Jacopo A.; Bonato, Matteo; La Torre, Antonio; Banfi, Giuseppe.

In: International Journal of Molecular Sciences, Vol. 20, No. 17, 03.09.2019.

Research output: Contribution to journalReview article

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