The role of the potassium channel gene KCNK2 in major depressive disorder

Chiara Congiu, Alessandra Minelli, Cristian Bonvicini, Marco Bortolomasi, Riccardo Sartori, Carlo Maj, Catia Scassellati, Giuseppe Maina, Luigi Trabucchi, Matilde Segala, Massimo Gennarelli

Research output: Contribution to journalArticlepeer-review

Abstract

Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalPsychiatry Research
Volume225
Issue number3
DOIs
Publication statusPublished - Feb 28 2015

Keywords

  • KCNK2
  • Major depressive disorder
  • Psychotic symptoms

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Medicine(all)

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