The role of the prefrontal cortex in sentence comprehension: An rTMS study

Rosa Manenti, Stefano F. Cappa, Paolo M. Rossini, Carlo Miniussi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Using repetitive transcranial magnetic stimulation (rTMS), we investigated the role of the left and right dorsolateral prefrontal cortex (DLPFC) in sentence comprehension. Subjects were required to judge which of the two pictures correctly matched the meaning of active and passive semantically reversible sentences (subject-verb-object); the incorrect picture did not match the sentence in term of lexical items (semantic task) or agent-patient structure (syntactic task). The subjects performed the task while a series of magnetic stimuli were applied to the left or right DLPFC. When rTMS was applied to the left DLPFC, the subjects' performance was delayed only for the semantic task, while rTMS applied to the right DLPFC slowed the processing of syntactic information. The results of this experiment provide direct evidence of a double dissociation between the rTMS effects and the type of task, which may reflect a differential hemispheric involvement of working memory resources during sentence comprehension.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalCortex
Volume44
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Transcranial Magnetic Stimulation
Prefrontal Cortex
Semantics
Proxy
Automatic Data Processing
Short-Term Memory

Keywords

  • DLPFC
  • Magnetic stimulation
  • Memory resources
  • Semantics
  • Syntax
  • TMS

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Neuroscience(all)
  • Clinical Neurology

Cite this

The role of the prefrontal cortex in sentence comprehension : An rTMS study. / Manenti, Rosa; Cappa, Stefano F.; Rossini, Paolo M.; Miniussi, Carlo.

In: Cortex, Vol. 44, No. 3, 2008, p. 337-344.

Research output: Contribution to journalArticle

Manenti, Rosa ; Cappa, Stefano F. ; Rossini, Paolo M. ; Miniussi, Carlo. / The role of the prefrontal cortex in sentence comprehension : An rTMS study. In: Cortex. 2008 ; Vol. 44, No. 3. pp. 337-344.
@article{81e560da3d9a44a490de8aa003dab782,
title = "The role of the prefrontal cortex in sentence comprehension: An rTMS study",
abstract = "Using repetitive transcranial magnetic stimulation (rTMS), we investigated the role of the left and right dorsolateral prefrontal cortex (DLPFC) in sentence comprehension. Subjects were required to judge which of the two pictures correctly matched the meaning of active and passive semantically reversible sentences (subject-verb-object); the incorrect picture did not match the sentence in term of lexical items (semantic task) or agent-patient structure (syntactic task). The subjects performed the task while a series of magnetic stimuli were applied to the left or right DLPFC. When rTMS was applied to the left DLPFC, the subjects' performance was delayed only for the semantic task, while rTMS applied to the right DLPFC slowed the processing of syntactic information. The results of this experiment provide direct evidence of a double dissociation between the rTMS effects and the type of task, which may reflect a differential hemispheric involvement of working memory resources during sentence comprehension.",
keywords = "DLPFC, Magnetic stimulation, Memory resources, Semantics, Syntax, TMS",
author = "Rosa Manenti and Cappa, {Stefano F.} and Rossini, {Paolo M.} and Carlo Miniussi",
year = "2008",
doi = "10.1016/j.cortex.2006.06.006",
language = "English",
volume = "44",
pages = "337--344",
journal = "Cortex",
issn = "0010-9452",
publisher = "Masson SpA",
number = "3",

}

TY - JOUR

T1 - The role of the prefrontal cortex in sentence comprehension

T2 - An rTMS study

AU - Manenti, Rosa

AU - Cappa, Stefano F.

AU - Rossini, Paolo M.

AU - Miniussi, Carlo

PY - 2008

Y1 - 2008

N2 - Using repetitive transcranial magnetic stimulation (rTMS), we investigated the role of the left and right dorsolateral prefrontal cortex (DLPFC) in sentence comprehension. Subjects were required to judge which of the two pictures correctly matched the meaning of active and passive semantically reversible sentences (subject-verb-object); the incorrect picture did not match the sentence in term of lexical items (semantic task) or agent-patient structure (syntactic task). The subjects performed the task while a series of magnetic stimuli were applied to the left or right DLPFC. When rTMS was applied to the left DLPFC, the subjects' performance was delayed only for the semantic task, while rTMS applied to the right DLPFC slowed the processing of syntactic information. The results of this experiment provide direct evidence of a double dissociation between the rTMS effects and the type of task, which may reflect a differential hemispheric involvement of working memory resources during sentence comprehension.

AB - Using repetitive transcranial magnetic stimulation (rTMS), we investigated the role of the left and right dorsolateral prefrontal cortex (DLPFC) in sentence comprehension. Subjects were required to judge which of the two pictures correctly matched the meaning of active and passive semantically reversible sentences (subject-verb-object); the incorrect picture did not match the sentence in term of lexical items (semantic task) or agent-patient structure (syntactic task). The subjects performed the task while a series of magnetic stimuli were applied to the left or right DLPFC. When rTMS was applied to the left DLPFC, the subjects' performance was delayed only for the semantic task, while rTMS applied to the right DLPFC slowed the processing of syntactic information. The results of this experiment provide direct evidence of a double dissociation between the rTMS effects and the type of task, which may reflect a differential hemispheric involvement of working memory resources during sentence comprehension.

KW - DLPFC

KW - Magnetic stimulation

KW - Memory resources

KW - Semantics

KW - Syntax

KW - TMS

UR - http://www.scopus.com/inward/record.url?scp=43549103355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43549103355&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2006.06.006

DO - 10.1016/j.cortex.2006.06.006

M3 - Article

C2 - 18387562

AN - SCOPUS:43549103355

VL - 44

SP - 337

EP - 344

JO - Cortex

JF - Cortex

SN - 0010-9452

IS - 3

ER -