The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients

Federica Menotti, Marika Berchicci, Francesco Di Russo, Antonello Damiani, Stefano Vitelli, Andrea Macaluso

Research output: Contribution to journalArticle

Abstract

This study aimed at comparing both peripheral and central mechanisms of muscle fatigue between Charcot-Marie-Tooth 1A patients and healthy individuals during a fatiguing voluntary task by simultaneous electromyographic and electroencephalographic recordings. Six Charcot-Marie-Tooth 1A patients (3 females, 40. ±. 11. years) and 6-matched healthy individuals performed four blocks of sub-maximal isometric knee extensions. At the beginning of the session and after each block, electrically-evoked maximal single-twitch, maximal voluntary contraction and surface-electromyography of the vastus lateralis muscle were measured. The movement-related-cortical potentials were averaged in early (block 1-2) and late (block 3-4) stages of fatigue. The effect of fatigue was demonstrated at peripheral level by the decline of maximal voluntary contraction, maximal twitch and surface electromyography amplitude and at central level by the larger amplitude of movement-related-cortical-potentials during late than early stage of fatiguing sub-maximal contractions. Charcot-Marie-Tooth 1A patients showed lower motor cortex activity during motor planning, with earlier onset and larger prefrontal cortex activity during the late stage of the fatiguing task than healthy controls. These data demonstrate the key role of the prefrontal cortex in the development of fatigue in Charcot-Marie-Tooth 1A patients, which may be activated as a compensatory mechanism for the low motor cortex activation, thus reflecting high awareness of movement complexity.

Original languageEnglish
Pages (from-to)516-523
Number of pages8
JournalNeuromuscular Disorders
Volume24
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Muscle Fatigue
Prefrontal Cortex
Tooth
Fatigue
Motor Cortex
Electromyography
Quadriceps Muscle
Knee
Motor Activity
Muscles

Keywords

  • Action anticipation
  • Electroencephalography (EEG)
  • Hereditary motor sensory neuropathy (HMSN)
  • Movement related cortical potentials (MRCPs)
  • Surface electromyography (sEMG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)
  • Neurology
  • Medicine(all)

Cite this

The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients. / Menotti, Federica; Berchicci, Marika; Di Russo, Francesco; Damiani, Antonello; Vitelli, Stefano; Macaluso, Andrea.

In: Neuromuscular Disorders, Vol. 24, No. 6, 2014, p. 516-523.

Research output: Contribution to journalArticle

Menotti, F, Berchicci, M, Di Russo, F, Damiani, A, Vitelli, S & Macaluso, A 2014, 'The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients', Neuromuscular Disorders, vol. 24, no. 6, pp. 516-523. https://doi.org/10.1016/j.nmd.2014.03.010
Menotti, Federica ; Berchicci, Marika ; Di Russo, Francesco ; Damiani, Antonello ; Vitelli, Stefano ; Macaluso, Andrea. / The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients. In: Neuromuscular Disorders. 2014 ; Vol. 24, No. 6. pp. 516-523.
@article{20b84024cba04a4ea117e3416ff4727b,
title = "The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients",
abstract = "This study aimed at comparing both peripheral and central mechanisms of muscle fatigue between Charcot-Marie-Tooth 1A patients and healthy individuals during a fatiguing voluntary task by simultaneous electromyographic and electroencephalographic recordings. Six Charcot-Marie-Tooth 1A patients (3 females, 40. ±. 11. years) and 6-matched healthy individuals performed four blocks of sub-maximal isometric knee extensions. At the beginning of the session and after each block, electrically-evoked maximal single-twitch, maximal voluntary contraction and surface-electromyography of the vastus lateralis muscle were measured. The movement-related-cortical potentials were averaged in early (block 1-2) and late (block 3-4) stages of fatigue. The effect of fatigue was demonstrated at peripheral level by the decline of maximal voluntary contraction, maximal twitch and surface electromyography amplitude and at central level by the larger amplitude of movement-related-cortical-potentials during late than early stage of fatiguing sub-maximal contractions. Charcot-Marie-Tooth 1A patients showed lower motor cortex activity during motor planning, with earlier onset and larger prefrontal cortex activity during the late stage of the fatiguing task than healthy controls. These data demonstrate the key role of the prefrontal cortex in the development of fatigue in Charcot-Marie-Tooth 1A patients, which may be activated as a compensatory mechanism for the low motor cortex activation, thus reflecting high awareness of movement complexity.",
keywords = "Action anticipation, Electroencephalography (EEG), Hereditary motor sensory neuropathy (HMSN), Movement related cortical potentials (MRCPs), Surface electromyography (sEMG)",
author = "Federica Menotti and Marika Berchicci and {Di Russo}, Francesco and Antonello Damiani and Stefano Vitelli and Andrea Macaluso",
year = "2014",
doi = "10.1016/j.nmd.2014.03.010",
language = "English",
volume = "24",
pages = "516--523",
journal = "Neuromuscular Disorders",
issn = "0960-8966",
publisher = "Elsevier Ltd",
number = "6",

}

TY - JOUR

T1 - The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients

AU - Menotti, Federica

AU - Berchicci, Marika

AU - Di Russo, Francesco

AU - Damiani, Antonello

AU - Vitelli, Stefano

AU - Macaluso, Andrea

PY - 2014

Y1 - 2014

N2 - This study aimed at comparing both peripheral and central mechanisms of muscle fatigue between Charcot-Marie-Tooth 1A patients and healthy individuals during a fatiguing voluntary task by simultaneous electromyographic and electroencephalographic recordings. Six Charcot-Marie-Tooth 1A patients (3 females, 40. ±. 11. years) and 6-matched healthy individuals performed four blocks of sub-maximal isometric knee extensions. At the beginning of the session and after each block, electrically-evoked maximal single-twitch, maximal voluntary contraction and surface-electromyography of the vastus lateralis muscle were measured. The movement-related-cortical potentials were averaged in early (block 1-2) and late (block 3-4) stages of fatigue. The effect of fatigue was demonstrated at peripheral level by the decline of maximal voluntary contraction, maximal twitch and surface electromyography amplitude and at central level by the larger amplitude of movement-related-cortical-potentials during late than early stage of fatiguing sub-maximal contractions. Charcot-Marie-Tooth 1A patients showed lower motor cortex activity during motor planning, with earlier onset and larger prefrontal cortex activity during the late stage of the fatiguing task than healthy controls. These data demonstrate the key role of the prefrontal cortex in the development of fatigue in Charcot-Marie-Tooth 1A patients, which may be activated as a compensatory mechanism for the low motor cortex activation, thus reflecting high awareness of movement complexity.

AB - This study aimed at comparing both peripheral and central mechanisms of muscle fatigue between Charcot-Marie-Tooth 1A patients and healthy individuals during a fatiguing voluntary task by simultaneous electromyographic and electroencephalographic recordings. Six Charcot-Marie-Tooth 1A patients (3 females, 40. ±. 11. years) and 6-matched healthy individuals performed four blocks of sub-maximal isometric knee extensions. At the beginning of the session and after each block, electrically-evoked maximal single-twitch, maximal voluntary contraction and surface-electromyography of the vastus lateralis muscle were measured. The movement-related-cortical potentials were averaged in early (block 1-2) and late (block 3-4) stages of fatigue. The effect of fatigue was demonstrated at peripheral level by the decline of maximal voluntary contraction, maximal twitch and surface electromyography amplitude and at central level by the larger amplitude of movement-related-cortical-potentials during late than early stage of fatiguing sub-maximal contractions. Charcot-Marie-Tooth 1A patients showed lower motor cortex activity during motor planning, with earlier onset and larger prefrontal cortex activity during the late stage of the fatiguing task than healthy controls. These data demonstrate the key role of the prefrontal cortex in the development of fatigue in Charcot-Marie-Tooth 1A patients, which may be activated as a compensatory mechanism for the low motor cortex activation, thus reflecting high awareness of movement complexity.

KW - Action anticipation

KW - Electroencephalography (EEG)

KW - Hereditary motor sensory neuropathy (HMSN)

KW - Movement related cortical potentials (MRCPs)

KW - Surface electromyography (sEMG)

UR - http://www.scopus.com/inward/record.url?scp=84901070263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901070263&partnerID=8YFLogxK

U2 - 10.1016/j.nmd.2014.03.010

DO - 10.1016/j.nmd.2014.03.010

M3 - Article

C2 - 24792521

AN - SCOPUS:84901070263

VL - 24

SP - 516

EP - 523

JO - Neuromuscular Disorders

JF - Neuromuscular Disorders

SN - 0960-8966

IS - 6

ER -