The role of the Purkinje network in premature ventricular complex-triggered ventricular fibrillation

Carola Gianni, J. David Burkhardt, Chintan Trivedi, Sanghamitra Mohanty, Andrea Natale

Research output: Contribution to journalArticle

Abstract

The Purkinje network (PN) is the distal part of the ventricular conduction system, which has shown to play a central role in the pathophysiology of ventricular fibrillation (VF). Abnormal automaticity and triggered activity are commonly seen in the PN, and the resulting premature ventricular complexes (PVCs) are frequently recognized as triggers of this life-threatening arrhythmia. Catheter ablation targeting PN-related PVCs can be successfully performed in patients with medically refractory VF in a variety of arrhythmic substrates.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalJournal of Interventional Cardiac Electrophysiology
Volume52
Issue number3
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • Catheter ablation
  • Purkinje network
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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