The Role of the Stem Cells Therapy in the Peripheral Artery Disease

Federico Biscetti, Nicola Bonadia, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

Research output: Contribution to journalReview articlepeer-review


Vascular complications of diabetes mellitus are an important issue for all clinicians involved in the management of this complex pathology. Although many therapeutic advances have been reached, peripheral arterial disease is still an unsolved problem that each year compromises the quality of life and life span of affected patients. Oftentimes, patients, after ineffective attempts of revascularization, undergo greater amputations. At the moment, there is no effective and definitive treatment available. In this scenario, the therapeutic use of stem cells could be an interesting option. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the stem cells therapy in this field, from biomarker to possible therapeutic target.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Issue number9
Publication statusPublished - May 7 2019


  • Animals
  • Clinical Trials as Topic
  • Diabetic Angiopathies/therapy
  • Humans
  • Peripheral Arterial Disease/therapy
  • Pluripotent Stem Cells/classification
  • Stem Cell Transplantation/adverse effects


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