Ruolo del sistema nervoso simpatico nell'ipertensione arteriosa essenziale e danno d'organo.

Translated title of the contribution: The role of the sympathetic nervous system in essential arterial hypertension and organ damage

G. Grassi, G. Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental evidence collected in animals and man supports the concept that adrenergic neural factors may be involved in the development of the hypertensive state and hypertension-related cardiovascular and metabolic complications. The various methodological approaches employed in evaluating sympathetic tone in man have shown that a hyperadrenergic state is evident in the early hypertensive phases. Sympathetic activation becomes more evident in stable hypertension and contributes to the maintenance of high blood pressure values. Adrenergic factors are also involved in the pathogenesis of cardiac and vascular hypertrophy, i.e. cardiovascular hypertensive complications that in the past have been regarded as mainly dependent on hemodynamic mechanisms. Sympathetic overactivity may also play an important role in the atherogenic process and may contribute to the insulin resistance state that often characterizes the hypertensive patient. The role of neural sympathetic factors in the pathophysiology of hypertension and its complications suggests that modulation of sympathetic activity should be an important target of modern antihypertensive treatment, aimed not only at lowering blood pressure, but also at reducing the patient's cardiovascular risk profile.

Translated title of the contributionThe role of the sympathetic nervous system in essential arterial hypertension and organ damage
Original languageItalian
JournalAnnali Italiani di Medicina Interna
Volume10 Suppl
Publication statusPublished - Oct 1995

ASJC Scopus subject areas

  • Internal Medicine

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