The Role of the Sympathetic Nervous System in the Long QT Syndrome: The Long Road from Pathophysiology to Therapy

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3 Citations (Scopus)

Abstract

This article reviews the role of the sympathetic nervous system in long QT syndrome (LQTS), in light of clinical and personal experience. The evolution of concepts related to LQTS is examined after 40 years of research and treatment. Studies stimulated by the sympathetic imbalance hypothesis have generated many unsuspected novel data and have provided an extremely strong rationale for the therapeutic use of left cardiac sympathetic denervation to prevent ventricular fibrillation, not only in LQTS but also in other life-threatening diseases associated with high risk for arrhythmic sudden death.

Original languageEnglish
Pages (from-to)75-85
Number of pages11
JournalCardiac Electrophysiology Clinics
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Long QT Syndrome
Sympathetic Nervous System
Sympathectomy
Therapeutic Uses
Ventricular Fibrillation
Sudden Death
Therapeutics
Research

Keywords

  • Arrhythmic sudden death
  • Left cardiac sympathetic denervation
  • Long QT syndrome
  • Sympathetic imbalance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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