Abstract
Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
| Original language | English |
|---|---|
| Journal | Head and Neck |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- compartmental tongue surgery
- lingual lymph nodes
- oral cancer
- squamous cell carcinoma
- tongue cancer
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
The role of the T-N tract in advanced stage tongue cancer. / Tagliabue, Marta; Gandini, Sara; Maffini, Fausto; Navach, Valeria; Bruschini, Roberto; Giugliano, Gioacchino; Lombardi, Francesca; Chiocca, Susanna; Rebecchi, Elisabetta; Sica, Eleonora; Tommasino, Massimo; Calabrese, Luca; Ansarin, Mohssen.
In: Head and Neck, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of the T-N tract in advanced stage tongue cancer
AU - Tagliabue, Marta
AU - Gandini, Sara
AU - Maffini, Fausto
AU - Navach, Valeria
AU - Bruschini, Roberto
AU - Giugliano, Gioacchino
AU - Lombardi, Francesca
AU - Chiocca, Susanna
AU - Rebecchi, Elisabetta
AU - Sica, Eleonora
AU - Tommasino, Massimo
AU - Calabrese, Luca
AU - Ansarin, Mohssen
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
AB - Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
KW - compartmental tongue surgery
KW - lingual lymph nodes
KW - oral cancer
KW - squamous cell carcinoma
KW - tongue cancer
UR - http://www.scopus.com/inward/record.url?scp=85063807235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063807235&partnerID=8YFLogxK
U2 - 10.1002/hed.25761
DO - 10.1002/hed.25761
M3 - Article
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
ER -