The role of the T-N tract in advanced stage tongue cancer

Research output: Contribution to journalArticle

Abstract

Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Tongue Neoplasms
Tongue
Proportional Hazards Models
Recurrence
Survival
Squamous Cell Carcinoma
Neck
Lymph Nodes
Neoplasm Metastasis
Incidence
Neoplasms

Keywords

  • compartmental tongue surgery
  • lingual lymph nodes
  • oral cancer
  • squamous cell carcinoma
  • tongue cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{c10e2526cdef483c931587b3abcba3fb,
title = "The role of the T-N tract in advanced stage tongue cancer",
abstract = "Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40{\%}) than did patients without T-N tract involvement (22{\%}; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95{\%} CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95{\%}CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.",
keywords = "compartmental tongue surgery, lingual lymph nodes, oral cancer, squamous cell carcinoma, tongue cancer",
author = "Marta Tagliabue and Sara Gandini and Fausto Maffini and Valeria Navach and Roberto Bruschini and Gioacchino Giugliano and Francesca Lombardi and Susanna Chiocca and Elisabetta Rebecchi and Eleonora Sica and Massimo Tommasino and Luca Calabrese and Mohssen Ansarin",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/hed.25761",
language = "English",
journal = "Head and Neck Surgery",
issn = "1043-3074",
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T1 - The role of the T-N tract in advanced stage tongue cancer

AU - Tagliabue, Marta

AU - Gandini, Sara

AU - Maffini, Fausto

AU - Navach, Valeria

AU - Bruschini, Roberto

AU - Giugliano, Gioacchino

AU - Lombardi, Francesca

AU - Chiocca, Susanna

AU - Rebecchi, Elisabetta

AU - Sica, Eleonora

AU - Tommasino, Massimo

AU - Calabrese, Luca

AU - Ansarin, Mohssen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.

AB - Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T-N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. Results: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P =.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P =.05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P =.02) in patients with “T-N tract involvement.”. Conclusions: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.

KW - compartmental tongue surgery

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