Abstract
TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.
| Original language | English |
|---|---|
| Pages (from-to) | 245-257 |
| Number of pages | 13 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2006 |
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Keywords
- Endothelial cells
- Hematopoiesis
- OPG
- TRAIL
- TRAIL receptors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
Cite this
The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology. / Zauli, Giorgio; Secchiero, Paola.
In: Cytokine and Growth Factor Reviews, Vol. 17, No. 4, 08.2006, p. 245-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology
AU - Zauli, Giorgio
AU - Secchiero, Paola
PY - 2006/8
Y1 - 2006/8
N2 - TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.
AB - TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.
KW - Endothelial cells
KW - Hematopoiesis
KW - OPG
KW - TRAIL
KW - TRAIL receptors
UR - http://www.scopus.com/inward/record.url?scp=33745854287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745854287&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2006.04.002
DO - 10.1016/j.cytogfr.2006.04.002
M3 - Article
C2 - 16750931
AN - SCOPUS:33745854287
VL - 17
SP - 245
EP - 257
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 4
ER -