The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

Giorgio Zauli; Paola Secchiero

doi:10.1016/j.cytogfr.2006.04.002

The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

Giorgio Zauli, Paola Secchiero

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.

Original language	English
Pages (from-to)	245-257
Number of pages	13
Journal	Cytokine and Growth Factor Reviews
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.cytogfr.2006.04.002
Publication status	Published - Aug 2006

Keywords

Endothelial cells
Hematopoiesis
OPG
TRAIL
TRAIL receptors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy

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10.1016/j.cytogfr.2006.04.002

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abstract = "TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.",

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AB - TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.

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KW - Hematopoiesis

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The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

Abstract

Keywords

ASJC Scopus subject areas

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