The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

Giorgio Zauli, Paola Secchiero

Research output: Contribution to journalArticlepeer-review

Abstract

TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system, comprising transmembrane (TRAIL-R1, -R2, -R3 and -R4) and soluble (osteoprotegerin) receptors. TRAIL has received considerable attention because of the finding that many cancer cell types are sensitive to TRAIL-induced apoptosis. However, increasing experimental evidence shows that TRAIL exhibits regulatory roles in various normal tissues, as well. Although the best-characterized biological activity of TRAIL is in the homeostatic regulation of the immune system, in this review we have summarized and discussed the physiological function of TRAIL and its receptors, in normal hematopoiesis and vascular physiopathology.

Original languageEnglish
Pages (from-to)245-257
Number of pages13
JournalCytokine and Growth Factor Reviews
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Endothelial cells
  • Hematopoiesis
  • OPG
  • TRAIL
  • TRAIL receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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