The role of the tumor microenvironment in hematological malignancies and implication for therapy

Jianbiao Zhou, Katja Mauerer, Lucia Farina, John G. Gribben

Research output: Contribution to journalArticlepeer-review


The tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion, and metastasis by providing survival signals and a sanctuary site for tumor cells, by secretion of growth factors, proangiogenesis factors and direct adhesion molecule interactions. Our knowledge of microenvironment is only now beginning to unfold. In this review, the morphological and molecular characteristics of microenvironment in various hematological malignancies including acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome, lymphoma, chronic lymphocytic leukemia, and multiple myeloma are summarized and the molecular mechanisms of microenvironment contributing to leukemogenesis are elucidated. We also aim to discuss the encouraging preclinical and clinical trials for treatment of hematological malignancies by targeting the tumor microenvironment. Further understanding of the signal transduction pathways between tumor cells and microenvironment will lead to the development of novel targeted therapeutic agents and more effective combination of current drugs for fighting hematological malignancies.

Original languageEnglish
Pages (from-to)1581-1596
Number of pages16
JournalFrontiers in Bioscience
Issue number2
Publication statusPublished - 2005


  • Angiogenesis
  • Hematological Malignancies
  • Leukemia
  • Multiple Myeloma
  • Novel Therapy
  • Review
  • Tumor Microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology


Dive into the research topics of 'The role of the tumor microenvironment in hematological malignancies and implication for therapy'. Together they form a unique fingerprint.

Cite this