The role of the tumor microenvironment in hematological malignancies and implication for therapy

Jianbiao Zhou, Katja Mauerer, Lucia Farina, John G. Gribben

Research output: Contribution to journalArticle

Abstract

The tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion, and metastasis by providing survival signals and a sanctuary site for tumor cells, by secretion of growth factors, proangiogenesis factors and direct adhesion molecule interactions. Our knowledge of microenvironment is only now beginning to unfold. In this review, the morphological and molecular characteristics of microenvironment in various hematological malignancies including acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome, lymphoma, chronic lymphocytic leukemia, and multiple myeloma are summarized and the molecular mechanisms of microenvironment contributing to leukemogenesis are elucidated. We also aim to discuss the encouraging preclinical and clinical trials for treatment of hematological malignancies by targeting the tumor microenvironment. Further understanding of the signal transduction pathways between tumor cells and microenvironment will lead to the development of novel targeted therapeutic agents and more effective combination of current drugs for fighting hematological malignancies.

Original languageEnglish
Pages (from-to)1581-1596
Number of pages16
JournalFrontiers in Bioscience
Volume10
Issue number2
Publication statusPublished - 2005

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Tumor Microenvironment
Hematologic Neoplasms
Tumors
Cellular Microenvironment
Myelodysplastic Syndromes
Drug Combinations
B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Cells
Signal Transduction
Lymphoma
Neoplasms
Intercellular Signaling Peptides and Proteins
Therapeutics
Signal transduction
Cell Proliferation
Clinical Trials
Neoplasm Metastasis

Keywords

  • Angiogenesis
  • Hematological Malignancies
  • Leukemia
  • Multiple Myeloma
  • Novel Therapy
  • Review
  • Tumor Microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

The role of the tumor microenvironment in hematological malignancies and implication for therapy. / Zhou, Jianbiao; Mauerer, Katja; Farina, Lucia; Gribben, John G.

In: Frontiers in Bioscience, Vol. 10, No. 2, 2005, p. 1581-1596.

Research output: Contribution to journalArticle

Zhou, Jianbiao ; Mauerer, Katja ; Farina, Lucia ; Gribben, John G. / The role of the tumor microenvironment in hematological malignancies and implication for therapy. In: Frontiers in Bioscience. 2005 ; Vol. 10, No. 2. pp. 1581-1596.
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