IL RUOLO DELLA COMPONENTE VASCOLARE NELL'ACCRESCIMENTO DEI TUMORI SOLIDI: RASSEGNA STORICA

Translated title of the contribution: The role of the vasculature in the growth of solid tumours: An historical review

D. Ribatti, A. Vacca

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Angiogenesis is a fundamental biological process by which new capillary blood vessels are formed. It is essential in many physiological conditions, such as embryonic development, ovulation and wound repair, and pathological ones, such as arthritis, diabetic retinopathy, and tumours. Solid tumours have angiogenesis capacity, and tumour growth and metastasis are angiogenesis dependent. Neoplastic cell populations can grow to form a clinically evident tumour only if the host produces a vascular network sufficient to sustain tumour growth. Furthermore, the new blood vessels provide a gateway for tumour cells to enter the circulation and metastasize to distant sites. Tumour angiogenesis is essentially mediated by angiogenic molecules elaborated by tumour cells. We review here the most important literature on this topic and emphasize the crucial and paradigmatic role of this biological process and its relevance in a possible anti-angiogenic therapeutic approach to the treatment of solid tumours.

Original languageItalian
Pages (from-to)92-95
Number of pages4
JournalAnnali Italiani di Medicina Interna
Volume9
Issue number2
Publication statusPublished - 1994

Fingerprint

Growth
Neoplasms
Blood Vessels
Biological Phenomena
Diabetic Retinopathy
Ovulation
Arthritis
Embryonic Development
Neoplasm Metastasis
Wounds and Injuries
Population
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

IL RUOLO DELLA COMPONENTE VASCOLARE NELL'ACCRESCIMENTO DEI TUMORI SOLIDI : RASSEGNA STORICA. / Ribatti, D.; Vacca, A.

In: Annali Italiani di Medicina Interna, Vol. 9, No. 2, 1994, p. 92-95.

Research output: Contribution to journalArticle

@article{243ced725189431f8729ce32a53384f6,
title = "IL RUOLO DELLA COMPONENTE VASCOLARE NELL'ACCRESCIMENTO DEI TUMORI SOLIDI: RASSEGNA STORICA",
abstract = "Angiogenesis is a fundamental biological process by which new capillary blood vessels are formed. It is essential in many physiological conditions, such as embryonic development, ovulation and wound repair, and pathological ones, such as arthritis, diabetic retinopathy, and tumours. Solid tumours have angiogenesis capacity, and tumour growth and metastasis are angiogenesis dependent. Neoplastic cell populations can grow to form a clinically evident tumour only if the host produces a vascular network sufficient to sustain tumour growth. Furthermore, the new blood vessels provide a gateway for tumour cells to enter the circulation and metastasize to distant sites. Tumour angiogenesis is essentially mediated by angiogenic molecules elaborated by tumour cells. We review here the most important literature on this topic and emphasize the crucial and paradigmatic role of this biological process and its relevance in a possible anti-angiogenic therapeutic approach to the treatment of solid tumours.",
author = "D. Ribatti and A. Vacca",
year = "1994",
language = "Italian",
volume = "9",
pages = "92--95",
journal = "Annali Italiani di Medicina Interna",
issn = "0393-9340",
publisher = "CEPI s.r.l.",
number = "2",

}

TY - JOUR

T1 - IL RUOLO DELLA COMPONENTE VASCOLARE NELL'ACCRESCIMENTO DEI TUMORI SOLIDI

T2 - RASSEGNA STORICA

AU - Ribatti, D.

AU - Vacca, A.

PY - 1994

Y1 - 1994

N2 - Angiogenesis is a fundamental biological process by which new capillary blood vessels are formed. It is essential in many physiological conditions, such as embryonic development, ovulation and wound repair, and pathological ones, such as arthritis, diabetic retinopathy, and tumours. Solid tumours have angiogenesis capacity, and tumour growth and metastasis are angiogenesis dependent. Neoplastic cell populations can grow to form a clinically evident tumour only if the host produces a vascular network sufficient to sustain tumour growth. Furthermore, the new blood vessels provide a gateway for tumour cells to enter the circulation and metastasize to distant sites. Tumour angiogenesis is essentially mediated by angiogenic molecules elaborated by tumour cells. We review here the most important literature on this topic and emphasize the crucial and paradigmatic role of this biological process and its relevance in a possible anti-angiogenic therapeutic approach to the treatment of solid tumours.

AB - Angiogenesis is a fundamental biological process by which new capillary blood vessels are formed. It is essential in many physiological conditions, such as embryonic development, ovulation and wound repair, and pathological ones, such as arthritis, diabetic retinopathy, and tumours. Solid tumours have angiogenesis capacity, and tumour growth and metastasis are angiogenesis dependent. Neoplastic cell populations can grow to form a clinically evident tumour only if the host produces a vascular network sufficient to sustain tumour growth. Furthermore, the new blood vessels provide a gateway for tumour cells to enter the circulation and metastasize to distant sites. Tumour angiogenesis is essentially mediated by angiogenic molecules elaborated by tumour cells. We review here the most important literature on this topic and emphasize the crucial and paradigmatic role of this biological process and its relevance in a possible anti-angiogenic therapeutic approach to the treatment of solid tumours.

UR - http://www.scopus.com/inward/record.url?scp=0027956014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027956014&partnerID=8YFLogxK

M3 - Articolo

C2 - 7522501

AN - SCOPUS:0027956014

VL - 9

SP - 92

EP - 95

JO - Annali Italiani di Medicina Interna

JF - Annali Italiani di Medicina Interna

SN - 0393-9340

IS - 2

ER -