The role of the vgf gene and VGF-derived peptides in nutrition and metabolism

Alessandro Bartolomucci, Roberta Possenti, Andrea Levi, Flaminia Pavone, Anna Moles

Research output: Contribution to journalArticlepeer-review


Energy homeostasis is a complex physiological function coordinated at multiple levels. The issue of genetic regulation of nutrition and metabolism is attracting increasing interest and new energy homeostasis-regulatory genes are continuously identified. Among these genes, vgf is gaining increasing interest following two observations: (1) VGF-/- mice have a lean and hypermetabolic phenotype; (2) the first VGF-derived peptide involved in energy homeostasis, named TLQP-21, has been identified. The aim of this review will be to discuss the role of the vgf gene and VGF derived peptides in metabolic and nutritional functions. In particular we will: (1) provide a brief overview on the central systems regulating energy homeostasis and nutrition particularly focusing on the melanocortin system; (2) introduce the structure and molecular characteristic of vgf; (3) describe the phenotype of VGF deficient mice; (4) present recent data on the metabolic role of VGF-derived peptides, particularly focusing on one peptide named TLQP-211.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalGenes and Nutrition
Issue number2
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

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