Abstract
In the last few years, the mechanistic role of thrombophilia due to hypercoagulability and of clonal disorders of hemopoiesis such as chromosome Philadelphia-negative chronic myeloproliferative disorders has been increasingly recognized in primary splanchnic vein thrombosis. As in deep venous thrombosis of the lower limbs, the frequent finding of several prothrombotic disorders in the same individual has led to the concept of primary splanchnic vein thrombosis as a multifactorial disease. Significant progress has been made in determining the molecular bases of inherited thrombophilia, and particularly in the identification of molecular markers of clonal disease in the so-called occult or latent myeloproliferative disorders. In this review article, the authors discuss the current knowledge on the role of thrombophilia in extrahepatic portal vein obstruction and in the Budd-Chiari syndrome, two of the most clinically relevant splanchnic vein thromboses.
| Original language | English |
|---|---|
| Pages (from-to) | 293-301 |
| Number of pages | 9 |
| Journal | Seminars in Liver Disease |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Keywords
- Hypercoagulability
- Myeloproliferative disorders
- Splanchnic vein thrombosis
- Thrombophilia
ASJC Scopus subject areas
- Hepatology
Cite this
The role of thrombophilia in splanchnic vein thrombosis. / Primignani, Massimo; Mannucci, Pier Mannuccio.
In: Seminars in Liver Disease, Vol. 28, No. 3, 08.2008, p. 293-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of thrombophilia in splanchnic vein thrombosis
AU - Primignani, Massimo
AU - Mannucci, Pier Mannuccio
PY - 2008/8
Y1 - 2008/8
N2 - In the last few years, the mechanistic role of thrombophilia due to hypercoagulability and of clonal disorders of hemopoiesis such as chromosome Philadelphia-negative chronic myeloproliferative disorders has been increasingly recognized in primary splanchnic vein thrombosis. As in deep venous thrombosis of the lower limbs, the frequent finding of several prothrombotic disorders in the same individual has led to the concept of primary splanchnic vein thrombosis as a multifactorial disease. Significant progress has been made in determining the molecular bases of inherited thrombophilia, and particularly in the identification of molecular markers of clonal disease in the so-called occult or latent myeloproliferative disorders. In this review article, the authors discuss the current knowledge on the role of thrombophilia in extrahepatic portal vein obstruction and in the Budd-Chiari syndrome, two of the most clinically relevant splanchnic vein thromboses.
AB - In the last few years, the mechanistic role of thrombophilia due to hypercoagulability and of clonal disorders of hemopoiesis such as chromosome Philadelphia-negative chronic myeloproliferative disorders has been increasingly recognized in primary splanchnic vein thrombosis. As in deep venous thrombosis of the lower limbs, the frequent finding of several prothrombotic disorders in the same individual has led to the concept of primary splanchnic vein thrombosis as a multifactorial disease. Significant progress has been made in determining the molecular bases of inherited thrombophilia, and particularly in the identification of molecular markers of clonal disease in the so-called occult or latent myeloproliferative disorders. In this review article, the authors discuss the current knowledge on the role of thrombophilia in extrahepatic portal vein obstruction and in the Budd-Chiari syndrome, two of the most clinically relevant splanchnic vein thromboses.
KW - Hypercoagulability
KW - Myeloproliferative disorders
KW - Splanchnic vein thrombosis
KW - Thrombophilia
UR - http://www.scopus.com/inward/record.url?scp=52949083194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52949083194&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1085097
DO - 10.1055/s-0028-1085097
M3 - Article
C2 - 18814082
AN - SCOPUS:52949083194
VL - 28
SP - 293
EP - 301
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 3
ER -