The role of thrombophilia in splanchnic vein thrombosis

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In the last few years, the mechanistic role of thrombophilia due to hypercoagulability and of clonal disorders of hemopoiesis such as chromosome Philadelphia-negative chronic myeloproliferative disorders has been increasingly recognized in primary splanchnic vein thrombosis. As in deep venous thrombosis of the lower limbs, the frequent finding of several prothrombotic disorders in the same individual has led to the concept of primary splanchnic vein thrombosis as a multifactorial disease. Significant progress has been made in determining the molecular bases of inherited thrombophilia, and particularly in the identification of molecular markers of clonal disease in the so-called occult or latent myeloproliferative disorders. In this review article, the authors discuss the current knowledge on the role of thrombophilia in extrahepatic portal vein obstruction and in the Budd-Chiari syndrome, two of the most clinically relevant splanchnic vein thromboses.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalSeminars in Liver Disease
Issue number3
Publication statusPublished - Aug 2008


  • Hypercoagulability
  • Myeloproliferative disorders
  • Splanchnic vein thrombosis
  • Thrombophilia

ASJC Scopus subject areas

  • Hepatology


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