The Role of Tissue Factor in Atherothrombosis and Coronary Artery Disease: Insights into Platelet Tissue Factor

Research output: Contribution to journalArticle

Abstract

The contribution of vessel wall-derived tissue factor (TF) to atherothrombosis is well established, whereas the pathophysiological relevance of the blood-borne TF is still a matter of debate, and controversies on the presence of platelet-associated TF still exist. In the past 15 years, several studies have documented the presence of TF in human platelets, the capacity of human platelets to use TF mRNA to make de novo protein synthesis, and the increase in the percentage of TF positive platelets in pathological conditions such as coronary artery disease (CAD). The exposure of vessel wall-derived TF at the site of vascular injury would play its main role in the initiation phase, whereas the blood-borne TF carried by platelets would be involved in the propagation phase of thrombus formation. More recent data indicate that megakaryocytes are committed to release into the bloodstream a well-defined number of TF-carrying platelets, which represents only a fraction of the whole platelet population. These findings are in line with the evidence that platelets are heterogeneous in their functions and only a subset of them is involved in the hemostatic process. In this review we summarize the existing knowledge on platelet associated TF and speculate on its relevance to physiology and to atherothrombosis and CAD.

Original languageEnglish
Pages (from-to)737-746
Number of pages10
JournalSeminars in Thrombosis and Hemostasis
Volume41
Issue number7
DOIs
Publication statusPublished - Sep 26 2015

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Thromboplastin
Coronary Artery Disease
Blood Platelets
Megakaryocytes
Vascular System Injuries
Hemostatics
Thrombosis
Messenger RNA

Keywords

  • atherothrombosis
  • coronary artery disease
  • megakaryocytes
  • platelets
  • tissue factor

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "The Role of Tissue Factor in Atherothrombosis and Coronary Artery Disease: Insights into Platelet Tissue Factor",
abstract = "The contribution of vessel wall-derived tissue factor (TF) to atherothrombosis is well established, whereas the pathophysiological relevance of the blood-borne TF is still a matter of debate, and controversies on the presence of platelet-associated TF still exist. In the past 15 years, several studies have documented the presence of TF in human platelets, the capacity of human platelets to use TF mRNA to make de novo protein synthesis, and the increase in the percentage of TF positive platelets in pathological conditions such as coronary artery disease (CAD). The exposure of vessel wall-derived TF at the site of vascular injury would play its main role in the initiation phase, whereas the blood-borne TF carried by platelets would be involved in the propagation phase of thrombus formation. More recent data indicate that megakaryocytes are committed to release into the bloodstream a well-defined number of TF-carrying platelets, which represents only a fraction of the whole platelet population. These findings are in line with the evidence that platelets are heterogeneous in their functions and only a subset of them is involved in the hemostatic process. In this review we summarize the existing knowledge on platelet associated TF and speculate on its relevance to physiology and to atherothrombosis and CAD.",
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author = "Marina Camera and Vincenzo Toschi and Marta Brambilla and Maddalena Lettino and Laura Rossetti and Paola Canzano and {Di Minno}, Alessandro and Elena Tremoli",
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AU - Camera, Marina

AU - Toschi, Vincenzo

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AU - Lettino, Maddalena

AU - Rossetti, Laura

AU - Canzano, Paola

AU - Di Minno, Alessandro

AU - Tremoli, Elena

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