The role of toll-like receptors in chronic fatigue syndrome/myalgic encephalomyelitis: A new promising therapeutic approach?

Maria Elsa Gambuzza, Francesca Maria Salmeri, Luca Soraci, Giulia Soraci, Vincenza Sofo, Silvia Marino, Placido Bramanti

Research output: Contribution to journalArticlepeer-review

Abstract

Perturbations in immune processes play an important role in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), a multifactorial disorder mainly characterized by severe and prolonged fatigue and tipically affecting a variety of bodily systems including the immune system. Recent reports have shown that CFS/ME is an inflammatory disorder may be associated with autoimmune responses, mainly characterized by reduced functional activity of most immune cells, including neutrophils, natural killer cells, monocytes/macrophage and dendritic cells, together with dysregulations in cytokine levels, responsible for changes in the adaptive immune system. Interactions between gut microorganisms and host immune function have been shown to contribute to aberrant inflammation in CFS/ME patients. Commensal and/or pathogen-associated molecular patterns detected by Toll-like receptors (TLRs) expressed on intestinal epithelial cells appear to trigger inflammatory signaling cascade leading to neuroinflammation and neurodegeneration. This paper examines the role of TLR-mediated innate immunity in CFS/ME with evaluation of the current literature, also discussing about innovative therapeutic approaches represented by immunomodulators TLR-targeting.

Original languageEnglish
Pages (from-to)903-914
Number of pages12
JournalCNS and Neurological Disorders - Drug Targets
Volume14
Issue number7
Publication statusPublished - Jul 1 2015

Keywords

  • Chronic fatigue syndrome/myalgic encephalomyelitis
  • Immune response dysregulation
  • Inflammation
  • Toll-like receptor-targeting compounds
  • Toll-like receptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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